PMC

Breakdown of Notify Library records by MPHO type (as of the end of September 2020). HPC, hematopoietic progenitor cell; MPHO, medical products of human origin.

Product code structure for other MPHO.

Entropic enzymes induce metabolic robustness. (A) We compare the downstream activity of a system with the entropic enzymes DPE2 (blue) and Pho (magenta) catalyzing the turnover of an SHG pool with a system which directly converts a fluctuating maltose input into glucose (G₁) and glucose-1-phosphate (G1P) using maltose phosphorylase (MPho, red). (B) The simulated temporally resolved output activity indicates that the higher entropy due to the SHG pool smears out the large fluctuation of the noisy maltose influx while the MPho system follows the fluctuations rapidly. The difference becomes dramatic in the case of very small maltose influx, where the downstream activity of the MPho system stops abruptly whereas the SHG buffer system can still provide energy from the pool of larger glucans. (C) The dependence of the G1P output on the maltose input demonstrates that the SHG pool acts as a buffer and ensures a robust support of downstream metabolism with carbon even under large and rapid external fluctuations, whereas the MPho system reacts strongly to changes in influx.

Product code structure for blood, cellular therapy, regenerated tissue products, fractionated plasma, and MPHO with INN or USAN.