PMC

PET images of THK compounds. [¹⁸F]AV-1451 (T807). [¹⁸F]AV-1451 (flortaucipir, T807) exhibited strong and selective binding affinity to PHF-tau on AD brain [, ]. With favourable pharmacokinetics and a binding pattern consistent with the Braak staging, [¹⁸F]AV-1451 is considered as the most promising PET candidates for tau imaging []. Clinical [¹⁸F]AV-1451 PET scans are demonstrated in Fig. . (THK-523 This research was originally published in Alzheimers Res. Ther) [] (THK-5105 and THK-5351 Images courtesy of Prof. Nobuyuki Okamura, Tohoku University) (THK-5117 Reprinted by permission from Copyright Clearance Center. This research was originally published in Springer Nature, Eur. J. Nucl. Med. Mol. Imaging [] Copyright (2015)

A schematic of a gold nanoshell-based complex for targeting of HER2 overexpressing ovarian cancer cells. Reprinted with permission from the American Association for Cancer Research: Chen W, Bardhan R, Bartels M, Perez-Torres C, Pautler RG, Halas NJ, et al. A molecularly targeted theranostic probe for ovarian cancer. Mol Cancer Ther 2010; 9(4): 1028–38.

Tissue distribution study of siRNA formulated in different LPD formulations. (A) FAM-labeled siRNA was formulated into LPD formulations and i.v. injected into nude mice through tail vein. After 4 hours, tumor and major organs were collected. FAM fluorescence signals were detected by Xenogen IVIS-100 imaging system. (B) Quantitative results of FAM-siRNA tissue distribution. Data =mean ±SD, n = 3–4. NP, nanoparticles. Reproduced with permission from, [], S. D. Li et al., Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Mol. Ther. 16, 163 (2008). © 2008.

(a) In vitro imaging analysis of genetically engineered hNSCs showing increasing Luc activity with cell density and a linear correlation (R² = 0.98). (b) Data are representative of 3 independent experiments performed in triplicate. (c–d) Representative BLI of stroke-lesioned rats transplanted with hNSCs and monitored for (c) 4 wks and (d) 8 wks post-transplantation. Quantitative analysis of Luc activity in these animals shows a stable BLI signal, suggestive of graft survival and the nonproliferative property of the hNSCs. Color scale bar is in photons/s/cm²/sr. (Reprinted with permission from Daadi MM, Li Z, Arac A, Grueter BA, Sofilos M, Malenka RC, Wu JC, Steinberg GK. Mol Ther 2009 Jul; 17(7): 1282-91.).