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Select item 26750401.

Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects

Alain Patat, Virginia Parks, Sangeeta Raje, Anna Plotka, Didier Chassard, F Le Coz

Br J Clin Pharmacol. 2009 Mar; 67(3): 299–308. doi: 10.1111/j.1365-2125.2008.03348.x

PMCID:: PMC2675040

Article PDF–760K

Select item 29480282.

Drug Development for Alzheimer's Disease: Where Are We Now and Where Are We Headed?

Marwan N. Sabbagh

Am J Geriatr Pharmacother. Author manuscript; available in PMC 2010 Sep 30.

Published in final edited form as: Am J Geriatr Pharmacother. 2009 Jun; 7(3): 167–185. doi: 10.1016/j.amjopharm.2009.06.003

PMCID:: PMC2948028

Article PDF–146K

Select item 26750373.

Early human studies of investigational agents: dose or microdose?

Lionel D Lewis

Br J Clin Pharmacol. 2009 Mar; 67(3): 277–279. doi: 10.1111/j.1365-2125.2009.03397.x

Correction in:: Br J Clin Pharmacol. 2009 Jun; 67(6): 695–694.

PMCID:: PMC2675037

Article PDF–300K

Select item 31136434.

Alzheimer’s Disease and Age-Related Memory Decline (Preclinical)

Alvin V. Terry, Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster

Pharmacol Biochem Behav. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: Pharmacol Biochem Behav. 2011 Aug; 99(2): 190–210. Published online 2011 Feb 24. doi: 10.1016/j.pbb.2011.02.002

PMCID:: PMC3113643

Article PDF–421K

Select item 90705675.

Medicinal Cannabis and Central Nervous System Disorders

Yuma T. Ortiz, Lance R. McMahon, Jenny L. Wilkerson

Front Pharmacol. 2022; 13: 881810. Published online 2022 Apr 21. doi: 10.3389/fphar.2022.881810

PMCID:: PMC9070567

Article PDF–1.4M

Select item 57932216.

Therapeutics of Neurotransmitters in Alzheimer’s Disease

Ramesh Kandimalla, P. Hemachandra Reddy

J Alzheimers Dis. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: J Alzheimers Dis. 2017; 57(4): 1049–1069. doi: 10.3233/JAD-161118

PMCID:: PMC5793221

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Select item 48468817.

An overview on therapeutics attenuating amyloid β level in Alzheimer’s disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels

Xiaoling Zhou, Yifei Li, Xiaozhe Shi, Chun Ma

Am J Transl Res. 2016; 8(2): 246–269. Published online 2016 Feb 15.

PMCID:: PMC4846881

Article PDF–846K

Select item 45282808.

The role of the serotonin receptor subtypes 5-HT_1A and 5-HT₇ and its interaction in emotional learning and memory

Oliver Stiedl, Elpiniki Pappa, Åsa Konradsson-Geuken, Sven Ove Ögren

Front Pharmacol. 2015; 6: 162. Published online 2015 Aug 7. doi: 10.3389/fphar.2015.00162

PMCID:: PMC4528280

Article PDF–856K

Select item 101901469.

Strategies for Treatment of Disease-Associated Dementia Beyond Alzheimer's Disease: An Update

Sabiya Samim Khan, Gopal L. Khatik, Ashok K. Datusalia

Curr Neuropharmacol. 2023 Feb 1; 21(2): 309–339. Published online 2023 Feb 1. doi: 10.2174/1570159X20666220411083922

PMCID:: PMC10190146

Article PDF–4.6M

Select item 487640910.

Selective serotonin 5-HT_1A receptor biased agonists elicitdistinct brain activation patterns: a pharmacoMRI study

G. Becker, R. Bolbos, N. Costes, J. Redouté, A. Newman-Tancredi, L. Zimmer

Sci Rep. 2016; 6: 26633. Published online 2016 May 23. doi: 10.1038/srep26633

PMCID:: PMC4876409

Article PDF–1.9M

Select item 732251911.

Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease

Alok Joshi, Da-Hui Wang, Steven Watterson, Paula L. McClean, Chandan K. Behera, Trevor Sharp, KongFatt Wong-Lin

Neuropharmacology. 2020 Sep 1; 174: 108118. doi: 10.1016/j.neuropharm.2020.108118

PMCID:: PMC7322519

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Select item 466778012.

Discovery of Natural Product-derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation

Man Luo, Terry-Elinor Reid, Xiang Simon Wang

Comb Chem High Throughput Screen. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Comb Chem High Throughput Screen. 2015; 18(7): 685–692. doi: 10.2174/1386207318666150703113948

PMCID:: PMC4667780

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Select item 271404313.

Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans

Marishka K Brown, Yuan Luo

BMC Neurosci. 2009; 10: 62. Published online 2009 Jun 22. doi: 10.1186/1471-2202-10-62

PMCID:: PMC2714043

Article PDF–335K

Select item 919988914.

Strategic, feasibility, economic, and cultural aspects of phase 0 approaches: Is it time to change the drug development process in order to increase productivity?

Tal Burt, Ad F. Roffel, Oliver Langer, Kirsten Anderson, Joseph DiMasi

Clin Transl Sci. 2022 Jun; 15(6): 1355–1379. Published online 2022 Apr 21. doi: 10.1111/cts.13269

PMCID:: PMC9199889

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Select item 984370215.

Clinical Trial Endpoints and Their Clinical Meaningfulness in Early Stages of Alzheimer’s Disease

S. Cohen, J. Cummings, S. Knox, M. Potashman, J. Harrison

J Prev Alzheimers Dis. Author manuscript; available in PMC 2023 Jan 17.

Published in final edited form as: J Prev Alzheimers Dis. 2022; 9(3): 507–522. doi: 10.14283/jpad.2022.41

PMCID:: PMC9843702

Article PDF–1.1M

Select item 908829316.

Uniting Amide Synthesis and Activation by P^III/P^V-Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines

Jeffrey M. Lipshultz, Alexander T. Radosevich

J Am Chem Soc. Author manuscript; available in PMC 2022 Sep 15.

Published in final edited form as: J Am Chem Soc. 2021 Sep 15; 143(36): 14487–14494. Published online 2021 Sep 3. doi: 10.1021/jacs.1c07608

PMCID:: PMC9088293

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Select item 876499817.

Regio- and Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines

Woo-Ok Jung, Minjin Yoo, Madyson M. Migliozzi, Jason R. Zbieg, Craig E. Stivala, Michael J. Krische

Org Lett. Author manuscript; available in PMC 2023 Jan 14.

Published in final edited form as: Org Lett. 2022 Jan 14; 24(1): 441–445. Published online 2021 Dec 14. doi: 10.1021/acs.orglett.1c04135

PMCID:: PMC8764998

Article PDF–1.1M

Select item 659118518.

Activation of somatodendritic 5-HT_1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test

Yulong Zhao, Elisabeth Y. Bijlsma, Freija ter Heegde, Monika P. Verdouw, J. Garssen, Adrian Newman-Tancredi, Lucianne Groenink

Psychopharmacology (Berl) 2019; 236(4): 1171–1185. Published online 2018 Dec 12. doi: 10.1007/s00213-018-5124-0

PMCID:: PMC6591185

Article PDF–962K

Select item 566044119.

In silico repurposing of antipsychotic drugs for Alzheimer’s disease

Shivani Kumar, Suman Chowdhury, Suresh Kumar

BMC Neurosci. 2017; 18: 76. Published online 2017 Oct 27. doi: 10.1186/s12868-017-0394-8

PMCID:: PMC5660441

Article PDF–2.1M

Select item 481473020.

Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT

Lieven D. Declercq, Rik Vandenberghe, Koen Van Laere, Alfons Verbruggen, Guy Bormans

Front Pharmacol. 2016; 7: 88. Published online 2016 Mar 31. doi: 10.3389/fphar.2016.00088

PMCID:: PMC4814730

Article PDF–1.3M

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