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Select item 87057841.

Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule

Giulia Vanti, Lucrezia Muti, Mario D’Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia

Molecules. 2021 Dec; 26(24): 7657. Published online 2021 Dec 17. doi: 10.3390/molecules26247657

PMCID:: PMC8705784

Article PDF–4.8M

Select item 36186682.

An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells

P. Vanachayangkul, K. Byer, S. Khan, V. Butterweck

Phytomedicine. Author manuscript; available in PMC 2013 Apr 6.

Published in final edited form as: Phytomedicine. 2010 Jul; 17(0): 653–658. Published online 2009 Dec 29. doi: 10.1016/j.phymed.2009.10.011

PMCID:: PMC3618668

Article PDF–2.8M

Select item 36639343.

Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats

P. Vanachayangkul, N. Chow, S.R. Khan, V. Butterweck

Urol Res. Author manuscript; available in PMC 2013 May 24.

Published in final edited form as: Urol Res. 2011 Jun; 39(3): 189–195. Published online 2010 Nov 11. doi: 10.1007/s00240-010-0333-y

PMCID:: PMC3663934

Article PDF–669K

Select item 62596194.

Synthesis of New Visnagen and Khellin Furochromone Pyrimidine Derivatives and Their Anti-Inflammatory and Analgesic Activity

Ameen Ali Abu-Hashem, Mohamed M. Youssef

Molecules. 2011 Mar; 16(3): 1956–1972. Published online 2011 Feb 25. doi: 10.3390/molecules16031956

PMCID:: PMC6259619

Article PDF–211K

Select item 79568475.

Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella (Ammi visnaga L.) Furanochromones and Their Cytotoxicity

Noha Khalil, Mokhtar Bishr, Mohamed El-Degwy, Mohamed Abdelhady, Mohamed Amin, Osama Salama

Molecules. 2021 Mar; 26(5): 1290. Published online 2021 Feb 27. doi: 10.3390/molecules26051290

PMCID:: PMC7956847

Article PDF–768K

Select item 10191406.

The Bronchodilator Action of Khellin

M. C. S. Kennedy, J. P. P. Stock

Thorax. 1952 Mar; 7(1): 43–65. doi: 10.1136/thx.7.1.43

PMCID:: PMC1019140

Summary Page Browse PDF–2.3M

Select item 59817887.

Khellin in the Treatment of Angina Pectoris

R. Hill, A. G. Melrose

Glasgow Med J. 1953 Jan; 34(1): 17–21.

PMCID:: PMC5981788

Summary Page Browse PDF–2.0M

Select item 4794278.

FURTHER EXPERIENCES WITH KHELLIN IN ANGINA OF EFFORT

H. A. Dewar, T. A. Grimson

Br Heart J. 1951 Jul; 13(3): 348–352. doi: 10.1136/hrt.13.3.348

PMCID:: PMC479427

Summary Page Browse PDF–564K

Select item 5036539.

KHELLIN IN THE TREATMENT OF ANGINA OF EFFORT

H. A. Dewar, T. A. Grimson

Br Heart J. 1950 Jan; 12(1): 54–60. doi: 10.1136/hrt.12.1.54

PMCID:: PMC503653

Summary Page Browse PDF–2.2M

Select item 43634610.

THE EFFECT OF KHELLIN ON CARDIO-PULMONARY FUNCTION IN CHRONIC PULMONARY DISEASE

E. N. Silber, G. L. Snider, H. Goldberg, L. N. Katz, D. B. Radner

J Clin Invest. 1951 Oct; 30(10): 1046–1054. doi: 10.1172/JCI102524

PMCID:: PMC436346

Summary Page Browse PDF–1.1M

Select item 746424611.

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Lorenzo Lisuzzo, Giuseppe Cavallaro, Stefana Milioto, Giuseppe Lazzara

Polymers (Basel) 2020 Aug; 12(8): 1766. Published online 2020 Aug 7. doi: 10.3390/polym12081766

PMCID:: PMC7464246

Article PDF–1.9M

Select item 129679412.

Gleb von Anrep.

A M Edwards

J R Soc Med. 1998 Jun; 91(6): 345. doi: 10.1177/014107689809100627

PMCID:: PMC1296794

Summary Page Browse PDF–207K

Select item 467897513.

Development and validation of high-performance liquid chromatography and high-performance thin-layer chromatography methods for the quantification of khellin in Ammi visnaga seed

Abid Kamal, Washim Khan, Sayeed Ahmad, F. J. Ahmad, Kishwar Saleem

J Pharm Bioallied Sci. 2015 Oct-Dec; 7(4): 308–313. doi: 10.4103/0975-7406.168033

PMCID:: PMC4678975

Select item 101758614.

A CLINICAL TRIAL OF PENTA-ERYTHRITOL TETRANITRATE, A KHELLIN DERIVATIVE (RECORDIL), AND IPRONIAZID IN ANGINA OF EFFORT

H. A. Dewar, A. R. Horler, D. J. Newell

Br Heart J. 1959 Jul; 21(3): 315–322. doi: 10.1136/hrt.21.3.315

PMCID:: PMC1017586

Summary Page Browse PDF–1.0M

Select item 748218315.

Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

Hai-rong Fu, Xiao-shan Li, Yong-hui Zhang, Bin-bin Feng, Lian-hong Pan

Eur J Histochem. 2020 Jun 19; 64(Suppl 2): 3131. Published online 2010 Sep 7. doi: 10.4081/ejh.2020.3131

PMCID:: PMC7482183

Article PDF–407K

Select item 664522516.

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1

Rajni Sharma, Ibidapo S. Williams, Linda Gatchie, Vinay R. Sonawane, Bhabatosh Chaudhuri, Sandip B. Bharate

ACS Omega. 2018 Aug 31; 3(8): 8553–8566. Published online 2018 Aug 1. doi: 10.1021/acsomega.8b01088

PMCID:: PMC6645225

Article PDF–2.7M

Select item 328800017.

F₄₂₀H₂-Dependent Degradation of Aflatoxin and other Furanocoumarins Is Widespread throughout the Actinomycetales

Gauri V. Lapalikar, Matthew C. Taylor, Andrew C. Warden, Colin Scott, Robyn J. Russell, John G. Oakeshott

PLoS One. 2012; 7(2): e30114. Published online 2012 Feb 27. doi: 10.1371/journal.pone.0030114

PMCID:: PMC3288000

Article PDF–555K

Select item 436098418.

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

Yan Liu, Aarti Asnani, Lin Zou, Victoria L. Bentley, Min Yu, You Wang, Graham Dellaire, Kumar S. Sarkar, Matthew Dai, Howard H. Chen, David E. Sosnovik, Jordan T. Shin, Daniel A. Haber, Jason N. Berman, Wei Chao, Randall T. Peterson

Sci Transl Med. Author manuscript; available in PMC 2015 Jun 10.

Published in final edited form as: Sci Transl Med. 2014 Dec 10; 6(266): 266ra170. doi: 10.1126/scitranslmed.3010189

PMCID:: PMC4360984

Article PDF–1.4M

Select item 839953919.

The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration

Giulia Vanti, Lorenzo Di Cesare Mannelli, Laura Micheli, Lorenzo Cinci, Lucia Grifoni, Maria Camilla Bergonzi, Carla Ghelardini, Anna Rita Bilia

Pharmaceutics. 2021 Aug; 13(8): 1275. Published online 2021 Aug 17. doi: 10.3390/pharmaceutics13081275

PMCID:: PMC8399539

Article PDF–3.0M

Select item 582532320.

Successful Treatment of Refractory Vitiligo with a Combination of Khellin and 308-nm Excimer Lamp: An Open-Label, 1-Year Prospective Study

Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami

Dermatol Ther (Heidelb) 2018 Mar; 8(1): 127–135. Published online 2017 Dec 27. doi: 10.1007/s13555-017-0218-x

PMCID:: PMC5825323

Article PDF–980K

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PMC Images search for Khellin

Figure 2

Thermogravimetric curves for Khellin, HNT and HNT/Khellin.

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Polymers (Basel). 2020 Aug;12(8):1766.
Figure 1

Chemical structure of khellin and visnagen.

Synthesis of New Visnagen and Khellin Furochromone Pyrimidine Derivatives and Their Anti-Inflammatory and Analgesic Activity

Molecules. 2011 Mar;16(3):1956-1972.
Figure 4

HPLC-DAD chromatogram of khellin at 246 nm.

Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule

Molecules. 2021 Dec;26(24):7657.
Figure 1Visnagin and khellin stimulate XRE-driven luciferase activity in AZ-AHR cells.

Stably transfected AZ-AHR cells were treated for 24 h with visnagin (VIS; 0.001 µM-20 µM), khellin (KHEL, 0.001 µM-20 µM), 5 µM 3MC and/or vehicle (DMSO; 0.1% v/v). Analyses were performed in four independent experiments and are expressed as fold induction over untreated cells. * - Value is significantly different from DMSO-treated cells (p < 0.05).

Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells

PLoS One. 2013;8(9):e74917.

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