A Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of culture under control conditions in cells from CTL, SCZ and MED. Structural parameters studied were; longest primary neurite (LPN), longest secondary neurite (LSN), number of primary neurites, number of secondary neurites and total number of neurites. Two-sample t tests was used to determine differences between CTL vs. SCZ and CTL vs. MED after a mixed model analysis was performed to account for correlations of repeated measures within subjects. Data are given as mean ± SEM. MDNCs from 8 CTL and 10 SCZ (of which 8 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 571; SCZ, n = 854; and MED, n = 667; for all other structural parameters; CTL, n = 656; SCZ, n = 976; and MED, n = 769. B Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of incubation with colchicine 0.4 µM in cells from CTL, SCZ and MED. The same structural parameters as in (A) were studied. We performed linear regression analysis adjusting for baseline retraction (response under control conditions), differentiation efficiency, and structure at baseline in the models as covariates based on subject-level averaged data. Data are given as mean ± SEM. MDNCs from 3 CTL and 7 SCZ (of which 6 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 117; SCZ, n = 341; and MED, n = 327; for all other structural parameters; CTL, n = 191; SCZ, n = 405; and MED, n = 388. C Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of incubation with colchicine 0.5 µM in cells from CTL, SCZ and MED. The same structural parameters and the same statistical analysis as in (A) were used. Data are given as mean ± SEM. MDNCs from 4 CTL and 9 SCZ (of which 8 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 267; SCZ, n = 565; and MED, n = 534; for all other structural parameters; CTL, n = 401; SCZ, n = 662; and MED, n = 627. D Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of incubation with colchicine 0.75 µM in cells from CTL, SCZ and MED. The same structural parameters and the same statistical analysis as in (A) were used. Data are given as mean ± SEM. MDNCs from 3 CTL and 7 SCZ (of which 6 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 221; SCZ, n = 490; and MED, n = 472; for all other structural parameters; CTL, n = 297; SCZ, n = 621; and MED, n = 593. E Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of incubation with dopamine 4mM in cells from CTL, SCZ and MED. The same structural parameters and the same statistical analysis as in (A) were used. Data are given as mean ± SEM. MDNCs from 6 CTL and 9 SCZ (of which 7 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 354; SCZ, n = 455; and MED, n = 414; for all other structural parameters; CTL, n = 477; SCZ, n = 622; and MED, n = 486. F Bar graphs contrasting the amount of pruning evidenced in MDNCs after an hour of incubation with dopamine 5 mM in cells from CTL, SCZ and MED. The same structural parameters and the same statistical analysis as in (A) were used. Data are given as mean ± SEM. MDNCs from 5 CTL and 7 SCZ (of which 6 are medicated “MED”) were included in the analysis. MDNCs traced for LSN for CTL, n = 228; SCZ, n = 316; and MED, n = 291; for all other structural parameters; CTL, n = 344; SCZ, n = 388; and MED, n = 352. *P = or < 0.05.