Epigallocatechin-3-Gallate - PMC

Mateusz Kciuk, Manzar Alam, Nemat Ali, Summya Rashid, Pola Głowacka, Rajamanikandan Sundaraj, Ismail Celik, Esam Bashir Yahya, Amit Dubey, Enfale Zerroug, Renata Kontek

Molecules. 2023 Jul; 28(13): 5246. Published online 2023 Jul 6. doi: 10.3390/molecules28135246

PMCID:: PMC10343677

Abstract Article PDF–4.6M

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Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer

Mehdi Sharifi-Rad, Raffaele Pezzani, Marco Redaelli, Maira Zorzan, Muhammad Imran, Anees Ahmed Khalil, Bahare Salehi, Farukh Sharopov, William C. Cho, Javad Sharifi-Rad

Molecules. 2020 Feb; 25(3): 467. Published online 2020 Jan 22. doi: 10.3390/molecules25030467

PMCID:: PMC7037968

Abstract Article PDF–865K

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Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka, Tomasz Łoziński, Mohamed Ali, Ayman Al-Hendy

Nutrients. 2024 Feb; 16(4): 559. Published online 2024 Feb 17. doi: 10.3390/nu16040559

PMCID:: PMC10893337

Abstract Article PDF–1.2M

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(−)-Epigallocatechin-3-Gallate Inhibits the Life Cycle of Pseudorabies Virus In Vitro and Protects Mice Against Fatal Infection

Changchao Huan, Weiyin Xu, Tingting Guo, Haochun Pan, Hengyue Zou, Luyao Jiang, Chengmin Li, Song Gao

Front Cell Infect Microbiol. 2020; 10: 616895. Published online 2021 Jan 14. doi: 10.3389/fcimb.2020.616895

PMCID:: PMC7841300

Abstract Article PDF–4.6M

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Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Wamidh H. Talib, Dima Awajan, Abdelrahim Alqudah, Razan Alsawwaf, Raha Althunibat, Mahmoud Abu AlRoos, Ala’a Al Safadi, Sharif Abu Asab, Rawan W. Hadi, Lina T. Al Kury

Molecules. 2024 Mar; 29(6): 1373. Published online 2024 Mar 20. doi: 10.3390/molecules29061373

PMCID:: PMC10976257

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Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

Wenru Li, Chaonan Zhu, Tianheng Liu, Weifang Zhang, Xu Liu, Peng Li, Tiantian Zhu

Diab Vasc Dis Res. 2020 Nov-Dec; 17(6): 1479164120966998. Published online 2020 Dec 6. doi: 10.1177/1479164120966998

PMCID:: PMC7919214

Abstract Article PDF–3.4M

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Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways

Mostafa D. Mostafa, Magda A ElKomy, Azza I. Othman, Maggie E. Amer, Mohamed A. El-Missiry

Neurotox Res. 2022; 40(6): 2103–2116. Published online 2022 Nov 17. doi: 10.1007/s12640-022-00605-4

PMCID:: PMC9797462

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The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Dongming Li, Donghui Cao, Yuanlin Sun, Yingnan Cui, Yangyu Zhang, Jing Jiang, Xueyuan Cao

Front Immunol. 2024; 15: 1331641. Published online 2024 Jan 29. doi: 10.3389/fimmu.2024.1331641

PMCID:: PMC10859531

Abstract Article PDF–9.3M

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Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity

Hiroki Tanabe, Takuji Suzuki, Tomokazu Ohishi, Mamoru Isemura, Yoriyuki Nakamura, Keiko Unno

Molecules. 2023 Jan; 28(2): 525. Published online 2023 Jan 5. doi: 10.3390/molecules28020525

PMCID:: PMC9862901

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Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?

Marta Menegazzi, Rachele Campagnari, Mariarita Bertoldi, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea

Int J Mol Sci. 2020 Jul; 21(14): 5171. Published online 2020 Jul 21. doi: 10.3390/ijms21145171

PMCID:: PMC7404268

Abstract Article PDF–821K

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Epigallocatechin Gallate Ameliorates the Effects of Prenatal Alcohol Exposure in a Fetal Alcohol Spectrum Disorder-Like Mouse Model

Laura Almeida-Toledano, Vicente Andreu-Fernández, Rosa Aras-López, Óscar García-Algar, Leopoldo Martínez, María Dolores Gómez-Roig

Int J Mol Sci. 2021 Jan; 22(2): 715. Published online 2021 Jan 13. doi: 10.3390/ijms22020715

PMCID:: PMC7828292

Abstract Article PDF–25M

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Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors

Changwei Liu, Penghui Li, Zhihao Qu, Wei Xiong, Ailing Liu, Sheng Zhang

Molecules. 2019 May; 24(9): 1726. Published online 2019 May 3. doi: 10.3390/molecules24091726

PMCID:: PMC6539113

Abstract Article PDF–1.0M

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Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells

Oskar Ciesielski, Marta Biesiekierska, Aneta Balcerczyk

Molecules. 2020 May; 25(10): 2326. Published online 2020 May 16. doi: 10.3390/molecules25102326

PMCID:: PMC7287656

Abstract Article PDF–4.9M

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Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems

Andreia Granja, Iúri Frias, Ana Rute Neves, Marina Pinheiro, Salette Reis

Biomed Res Int. 2017; 2017: 5813793. Published online 2017 Jul 16. doi: 10.1155/2017/5813793

PMCID:: PMC5534279

Abstract Article PDF–981K

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Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

Priscila Baltazar Gonçalves, Ana Carolina Rennó Sodero, Yraima Cordeiro

Biomolecules. 2021 May; 11(5): 767. Published online 2021 May 20. doi: 10.3390/biom11050767

PMCID:: PMC8160836

Abstract Article PDF–7.6M

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Epigallocatechin Gallate for Management of Heavy Metal-Induced Oxidative Stress: Mechanisms of Action, Efficacy, and Concerns

Iwona Zwolak

Int J Mol Sci. 2021 Apr; 22(8): 4027. Published online 2021 Apr 14. doi: 10.3390/ijms22084027

PMCID:: PMC8070748

Abstract Article PDF–1.7M

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Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers

Yun-Ju Huang, Kai-Lee Wang, Hsin-Yuan Chen, Yi-Fen Chiang, Shih-Min Hsia

Biomolecules. 2020 Nov; 10(11): 1481. Published online 2020 Oct 25. doi: 10.3390/biom10111481

PMCID:: PMC7694163

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The Effects of Epigallocatechin-3-Gallate Nutritional Supplementation in the Management of Multiple Sclerosis: A Systematic Review of Clinical Trials

Amanda Claudia Schuldesz, Raluca Tudor, Prashant Sunil Nandarge, Ahmed Elagez, Amalia Cornea, Radu Ion, Felix Bratosin, Mihaela Prodan, Mihaela Simu

Nutrients. 2024 Aug; 16(16): 2723. Published online 2024 Aug 15. doi: 10.3390/nu16162723

PMCID:: PMC11356828

Abstract Article PDF–1.0M

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Figure 6.

Effect of EGCG on pancreatic ROS levels, which were determined by dihydroethidium staining (200×).
EGCG (L): epigallocatechin-3-gallate 25 mg/kg/day; EGCG (M): epigallocatechin-3-gallate 50 mg/kg/day; EGCG (H): epigallocatechin-3-gallate 100 mg/kg; ROS: reactive oxygen species.

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

Diab Vasc Dis Res. 2020 Nov-Dec;17(6):1479164120966998.
Figure 1 Masson’s trichrome staining. Evidence of fibrosis (collagen content) was more prominent in bleomycin group than bleomycin + epigallocatechin-3-gallate group. Original magnification ¥20. (a) Control group, (b) bleomycin group, (c) bleomycin+epigallocatechin-3-gallate group, (d) epigallocatechin-3-gallate group. BLM: Bleomycin; EGCG: Epigallocatechin-3-gallate.

Antioxidant Effect of Epigallocatechin-3-Gallate in a Bleomycin-Induced Scleroderma Model

Arch Rheumatol. 2019 Mar;34(1):1-8.
Figure 2Epigallocatechin-3-gallate increased superoxide dismutase activity and decreased malondialdehyde activity (** p<0.05). SOD: Superoxide dismutase; BLM: Bleomycin; EGCG: Epigallocatechin-3-gallate; MDA: Malondialdehyde.

Antioxidant Effect of Epigallocatechin-3-Gallate in a Bleomycin-Induced Scleroderma Model

Arch Rheumatol. 2019 Mar;34(1):1-8.
Figure 5.

Effect of EGCG on SOD and MDA levels in experimental rats. (a) SOD and (b) MDA levels of experimental rats.
EGCG (L): epigallocatechin-3-gallate 25 mg/kg/day; EGCG (M): epigallocatechin-3-gallate 50 mg/kg/day; EGCG (H): epigallocatechin-3-gallate 100 mg/kg; MDA: malondialdehyde; SOD: superoxide dismutase. **p ⩽ 0.01 versus control; ^##p ⩽ 0.01 versus model. Results are presented as mean ± SEM (n = 6).

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

Diab Vasc Dis Res. 2020 Nov-Dec;17(6):1479164120966998.