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Items: 1 to 20 of 121

1.
Which Endpoints Should be Applied in Interventional Trials? –: From Single Uni-dimensional Assessment Tailored to a Drug’s Mechanism of Action to Multi-Component Measures and Multi-Domain Composites
Felix Eckstein, Tanja Stamm, Jamie Collins
Osteoarthr Imaging. Author manuscript; available in PMC 2025 Mar 28.
Published in final edited form as: Osteoarthr Imaging. 2025 Mar; 5(1): 100256. Published online 2024 Dec 25. doi: 10.1016/j.ostima.2024.100256
PMCID:
PMC11951169
ArticlePDF–643K
2.
Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss
Frank W. Roemer, Mylène P. Jansen, Susanne Maschek, Simon C. Mastbergen, Anne-Karien Marijnissen, Anna Wisser, Rafael Heiss, Harrie H. Weinans, Francisco J. Blanco, Francis Berenbaum, Margreet Kloppenburg, Ida K. Haugen, Felix Eckstein, David J. Hunter, Ali Guermazi, Wolfgang Wirth
Cartilage. 2024 Oct 26 : 19476035241287694. doi: 10.1177/19476035241287694 [Epub ahead of print]
PMCID:
PMC11556660
ArticlePDF–918K
3.
Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study
Felix Eckstein, Susanne Maschek, Wolfgang Wirth, Christoph Ladel, Asger Reinstrup Bihlet, Chris Knight, Kenneth Somberg, Luping Zhao
Osteoarthr Cartil Open. 2024 Dec; 6(4): 100513. Published online 2024 Aug 23. doi: 10.1016/j.ocarto.2024.100513
PMCID:
PMC11403365
ArticlePDF–691K
4.
Worsening of Articular Tissue Damage as Defined by Semi-Quantitative MRI Is Associated With Concurrent Quantitative Cartilage Loss Over 24 Months
Frank Roemer, Susanne Maschek, Anna Wisser, Ali Guermazi, David Hunter, Felix Eckstein, Wolfgang Wirth
Cartilage. 2023 Mar; 14(1): 39–47. Published online 2023 Jan 9. doi: 10.1177/19476035221147677
PMCID:
PMC10076901
ArticlePDF–391K
5.
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
Frank W. Roemer, Mylène Jansen, Anne C. A. Marijnissen, Ali Guermazi, Rafael Heiss, Susanne Maschek, Agnes Lalande, Francisco J. Blanco, Francis Berenbaum, Lotte A. van de Stadt, Margreet Kloppenburg, Ida K. Haugen, Christoph H. Ladel, Jaume Bacardit, Anna Wisser, Felix Eckstein, Floris P. J. G. Lafeber, Harrie H. Weinans, Wolfgang Wirth
BMC Musculoskelet Disord. 2022; 23: 988. Published online 2022 Nov 17. doi: 10.1186/s12891-022-05926-1
PMCID:
PMC9670371
ArticlePDF–1.0M
6.
Quantitative measurement of cartilage morphology in osteoarthritis: current knowledge and future directions
Wolfgang Wirth, Christoph Ladel, Susanne Maschek, Anna Wisser, Felix Eckstein, Frank Roemer
Skeletal Radiol. 2023; 52(11): 2107–2122. Published online 2022 Nov 15. doi: 10.1007/s00256-022-04228-w
PMCID:
PMC10509082
ArticlePDF–1.2M
7.
Presence of MRI-defined inflammation particularly in overweight and obese women increases risk of radiographic knee osteoarthritis: the POMA Study
Frank W. Roemer, Ali Guermazi, Michael J. Hannon, Tomoko Fujii, Patrick Omoumi, David J. Hunter, Felix Eckstein, C. Kent Kwoh
Arthritis Care Res (Hoboken) Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: Arthritis Care Res (Hoboken). 2022 Aug; 74(8): 1391–1398. Published online 2022 May 11. doi: 10.1002/acr.24568
PMCID:
PMC8326300
ArticlePDF–279K
8.
Detection of Differences in Longitudinal Cartilage Thickness Loss Using a Deep‐Learning Automated Segmentation Algorithm: Data From the Foundation for the National Institutes of Health Biomarkers Study of the Osteoarthritis Initiative
Felix Eckstein, Akshay S. Chaudhari, David Fuerst, Martin Gaisberger, Jana Kemnitz, Christian F. Baumgartner, Ender Konukoglu, David J. Hunter, Wolfgang Wirth
Arthritis Care Res (Hoboken) 2022 Jun; 74(6): 929–936. Published online 2022 Apr 1. doi: 10.1002/acr.24539
PMCID:
PMC9321555
ArticlePDF–282K
9.
The longitudinal relationship between tibiofemoral contact stress at baseline and worsening of knee pain over 84-months in The Multicenter Osteoarthritis Study
Kaitlin G Rabe, Tyler J Stockman, Andrew M Kern, Wolfgang Wirth, Felix Eckstein, Leena Sharma, John A Lynch, Michael Nevitt, Donald D Anderson, Neil A Segal
Am J Phys Med Rehabil. Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: Am J Phys Med Rehabil. 2022 Aug 1; 101(8): 726–732. Published online 2021 Oct 8. doi: 10.1097/PHM.0000000000001899
PMCID:
PMC8986881
ArticlePDF–1.0M
10.
Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative
Kalpana Sharma, Felix Eckstein, Wolfgang Wirth, Katja Emmanuel
Skeletal Radiol. 2022; 51(5): 997–1006. Published online 2021 Sep 30. doi: 10.1007/s00256-021-03911-8
PMCID:
PMC8930934
ArticlePDF–999K
11.
Changes in Cartilage Thickness and Denuded Bone Area after Knee Joint Distraction and High Tibial Osteotomy—Post-Hoc Analyses of Two Randomized Controlled Trials
Mylène P. Jansen, Susanne Maschek, Ronald J. van Heerwaarden, Simon C. Mastbergen, Wolfgang Wirth, Floris P. J. G. Lafeber, Felix Eckstein
J Clin Med. 2021 Jan; 10(2): 368. Published online 2021 Jan 19. doi: 10.3390/jcm10020368
PMCID:
PMC7835945
ArticlePDF–1.7M
12.
Longitudinal Change in Knee Cartilage Thickness and Function in Subjects with and without MRI-Diagnosed Cartilage Damage
Anna Wisser, Andreas Lapper, Frank Roemer, David Fuerst, Susanne Maschek, Wolfgang Wirth, Georg N. Duda, Felix Eckstein
Cartilage. 2021 Dec; 13(1 Suppl): 685S–693S. Published online 2020 Dec 24. doi: 10.1177/1947603520980157
PMCID:
PMC8808787
ArticlePDF–802K
13.
Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial
Felix Eckstein, Jeffrey L Kraines, Aida Aydemir, Wolfgang Wirth, Susanne Maschek, Marc C Hochberg
Ann Rheum Dis. 2020 Apr; 79(4): 525–528. Published online 2020 Feb 25. doi: 10.1136/annrheumdis-2019-216453
PMCID:
PMC7147175
ArticlePDF–454K
14.
REDUCTION IN THIGH MUSCLE STRENGTH OCCURS CONCURRENTLY, BUT DOES NOT APPEAR TO PRECEDE INCIDENT KNEE PAIN IN WOMEN: DATA FROM THE OSTEOARTHRITIS INITIATIVE COHORT
Anja Ruhdorfer, Wolfgang Wirth, Adam G Culvenor, Felix Eckstein
Am J Phys Med Rehabil. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Am J Phys Med Rehabil. 2020 Jan; 99(1): 33–40. doi: 10.1097/PHM.0000000000001271
PMCID:
PMC6920538
ArticlePDF–588K
15.
Clinical evaluation of fully automated thigh muscle and adipose tissue segmentation using a U-Net deep learning architecture in context of osteoarthritic knee pain
Jana Kemnitz, Christian F. Baumgartner, Felix Eckstein, Akshay Chaudhari, Anja Ruhdorfer, Wolfgang Wirth, Sebastian K. Eder, Ender Konukoglu
MAGMA. 2020; 33(4): 483–493. Published online 2019 Dec 23. doi: 10.1007/s10334-019-00816-5
PMCID:
PMC7351818
ArticlePDF–2.8M
16.
The effects of intensive dietary weight loss and exercise on gait in overweight and obese adults with knee osteoarthritis. The Intensive Diet and Exercise for Arthritis (IDEA) trial
Stephen P. Messier, Daniel P. Beavers, Shannon L. Mihalko, Gary D. Miller, Mary F. Lyles, David J. Hunter, J. Jeffery Carr, Felix Eckstein, Ali Guermazi, Richard F. Loeser, Paul DeVita
J Biomech. Author manuscript; available in PMC 2021 Jan 2.
Published in final edited form as: J Biomech. 2020 Jan 2; 98: 109477. Published online 2019 Oct 31. doi: 10.1016/j.jbiomech.2019.109477
PMCID:
PMC6949016
ArticlePDF–854K
17.
Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial
Marc C. Hochberg, Ali Guermazi, Hans Guehring, Aida Aydemir, Stephen Wax, Patricia Fleuranceau-Morel, Asger Reinstrup Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Felix Eckstein
JAMA. 2019 Oct 8; 322(14): 1360–1370. Published online 2019 Oct 8. doi: 10.1001/jama.2019.14735
PMCID:
PMC6784851
Article
18.
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
Heide Boeth, Peter C. Raffalt, Aoife MacMahon, A. Robin Poole, Felix Eckstein, Wolfgang Wirth, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N. Duda
J Exp Orthop. 2019 Dec; 6: 19. Published online 2019 May 3. doi: 10.1186/s40634-019-0179-3
PMCID:
PMC6499840
ArticlePDF–1.4M
19.
Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better?
Stephen P. Messier, Allison E. Resnik, Daniel P. Beavers, Shannon L. Mihalko, Gary D. Miller, Barbara J. Nicklas, Paul DeVita, David J. Hunter, Mary F. Lyles, Felix Eckstein, Ali Guermazi, Richard F. Loeser
Arthritis Care Res (Hoboken) Author manuscript; available in PMC 2019 Nov 1.
Published in final edited form as: Arthritis Care Res (Hoboken). 2018 Nov; 70(11): 1569–1575. doi: 10.1002/acr.23608
PMCID:
PMC6203601
ArticlePDF–323K
20.
Is local or central adiposity more strongly associated with incident knee osteoarthritis than the body mass index in men or women?
Adam G Culvenor, David T Felson, Wolfgang Wirth, Torben Dannhauer, Felix Eckstein
Osteoarthritis Cartilage. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: Osteoarthritis Cartilage. 2018 Aug; 26(8): 1033–1037. Published online 2018 May 25. doi: 10.1016/j.joca.2018.05.006
PMCID:
PMC6050106
ArticlePDF–66K

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