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Select item 80929211.

Curcumin restores innate immune Alzheimer’s disease risk gene expression to ameliorate Alzheimer pathogenesis

B. Teter, T. Morihara, G.P. Lim, T. Chu, M.R. Jones, X. Zuo, R.M. Paul, S.A. Frautschy, G.M. Cole

Neurobiol Dis. Author manuscript; available in PMC 2021 May 3.

Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 432–448. Published online 2019 Apr 2. doi: 10.1016/j.nbd.2019.02.015

PMCID:: PMC8092921

Abstract Article PDF–1.5M

Select item 94105772.

A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease

Xinyan Wu, Xiaomei Zheng, Huaqiao Tang, Ling Zhao, Changliang He, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Gang Ye

Medicine (Baltimore) 2022 Aug 26; 101(34): e30194. Published online 2022 Aug 26. doi: 10.1097/MD.0000000000030194

PMCID:: PMC9410577

Abstract Article PDF–3.4M

Select item 87698573.

A New Perspective on the Treatment of Alzheimer's Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Esra Küpeli Akkol, Hilal Bardakcı, Çiğdem Yücel, Gökçe Şeker Karatoprak, Büşra Karpuz, Haroon Khan

Oxid Med Cell Longev. 2022; 2022: 6168199. Published online 2022 Jan 12. doi: 10.1155/2022/6168199

PMCID:: PMC8769857

Abstract Article PDF–1.1M

Select item 77953674.

Curcumin and Its Derivatives as Theranostic Agents in Alzheimer’s Disease: The Implication of Nanotechnology

Umair Shabbir, Momna Rubab, Akanksha Tyagi, Deog-Hwan Oh

Int J Mol Sci. 2021 Jan; 22(1): 196. Published online 2020 Dec 27. doi: 10.3390/ijms22010196

PMCID:: PMC7795367

Abstract Article PDF–1.8M

Select item 60836245.

Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics

Jurre den Haan, Tjado H. J. Morrema, Annemieke J. Rozemuller, Femke H. Bouwman, Jeroen J. M. Hoozemans

Acta Neuropathol Commun. 2018; 6: 75. Published online 2018 Aug 9. doi: 10.1186/s40478-018-0577-2

PMCID:: PMC6083624

Abstract Article PDF–5.7M

Select item 57967616.

Protective Effects of Indian Spice Curcumin Against Amyloid Beta in Alzheimer’s Disease

P. Hemachandra Reddy, Maria Manczak, Xiangling Yin, Mary Catherine Grady, Andrew Mitchell, Sahil Tonk, Chandra Sekhar Kuruva, Jasvinder Singh Bhatti, Ramesh Kandimalla, Murali Vijayan, Subodh Kumar, Rui Wang, Jangampalli Adi Pradeepkiran, Gilbert Ogunmokun, Kavya Thamarai, Kandi Quesada, Annette Boles, Arubala P Reddy

J Alzheimers Dis. Author manuscript; available in PMC 2018 Feb 2.

Published in final edited form as: J Alzheimers Dis. 2018; 61(3): 843–866. doi: 10.3233/JAD-170512

PMCID:: PMC5796761

Abstract Article PDF–689K

Select item 71398867.

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

Eirini Chainoglou, Dimitra Hadjipavlou-Litina

Int J Mol Sci. 2020 Mar; 21(6): 1975. Published online 2020 Mar 13. doi: 10.3390/ijms21061975

PMCID:: PMC7139886

Abstract Article PDF–4.1M

Select item 92274598.

Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research

Haijun Yang, Fantian Zeng, Yunchun Luo, Chao Zheng, Chongzhao Ran, Jian Yang

Molecules. 2022 Jun; 27(12): 3879. Published online 2022 Jun 17. doi: 10.3390/molecules27123879

PMCID:: PMC9227459

Abstract Article PDF–2.1M

Select item 110848549.

Combination of Tramiprosate, Curcumin, and SP600125 Reduces the Neuropathological Phenotype in Familial Alzheimer Disease PSEN1 I416T Cholinergic-like Neurons

Nicolas Gomez-Sequeda, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo

Int J Mol Sci. 2024 May; 25(9): 4925. Published online 2024 Apr 30. doi: 10.3390/ijms25094925

PMCID:: PMC11084854

Abstract Article PDF–9.5M

Select item 931903110.

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Siyu Liu, Jie Liu, Lan He, Liu Liu, Bo Cheng, Fangliang Zhou, Deliang Cao, Yingchun He

Molecules. 2022 Jul; 27(14): 4400. Published online 2022 Jul 8. doi: 10.3390/molecules27144400

PMCID:: PMC9319031

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Select item 1080012711.

Nanocarrier-mediated curcumin delivery: An adjuvant strategy for CNS disease treatment

Sandip Godse, Lina Zhou, Swarna Sakshi, Bhupesh Singla, Udai P Singh, Santosh Kumar

Exp Biol Med (Maywood) 2023 Nov; 248(22): 2151–2166. Published online 2023 Dec 6. doi: 10.1177/15353702231211863

PMCID:: PMC10800127

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Select item 877903812.

Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Possible Therapeutic Role of Curcumin

Ryszard Pluta, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Stanisław J. Czuczwar

Nutrients. 2022 Jan; 14(2): 248. Published online 2022 Jan 7. doi: 10.3390/nu14020248

PMCID:: PMC8779038

Abstract Article PDF–1.8M

Select item 941379113.

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease

Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Thozhukat Sathyapalan, Muhammed Majeed, Amirhossein Sahebkar

Curr Neuropharmacol. 2022 Feb 17; 20(2): 309–323. Published online 2022 Feb 17. doi: 10.2174/1570159X19666210823103020

PMCID:: PMC9413791

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Select item 640676214.

Formulations of Curcumin Nanoparticles for Brain Diseases

María L. Del Prado-Audelo, Isaac H. Caballero-Florán, Jorge A. Meza-Toledo, Néstor Mendoza-Muñoz, Maykel González-Torres, Benjamín Florán, Hernán Cortés, Gerardo Leyva-Gómez

Biomolecules. 2019 Feb; 9(2): 56. Published online 2019 Feb 8. doi: 10.3390/biom9020056

PMCID:: PMC6406762

Abstract Article PDF–2.9M

Select item 1135752415.

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Yandra Cervelim Nunes, Nathalia M. Mendes, Enzo Pereira de Lima, Amanda Chabrour Chehadi, Caroline Barbalho Lamas, Jesselina F. S. Haber, Manoela dos Santos Bueno, Adriano Cressoni Araújo, Vitor C. Strozze Catharin, Claudia Rucco P. Detregiachi, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho, Maria José Sanches Marin

Nutrients. 2024 Aug; 16(16): 2721. Published online 2024 Aug 15. doi: 10.3390/nu16162721

PMCID:: PMC11357524

Abstract Article PDF–5.8M

Select item 600822116.

Revolution of Alzheimer Precision Neurology: Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Jean Lorenceau, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Craig Ritchie, Simone Rossi, Emiliano Santarnecchi, Olaf Sporns, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Erfan Younesi, Francesco Garaci, Simone Lista

J Alzheimers Dis. Author manuscript; available in PMC 2018 Jun 19.

Published in final edited form as: J Alzheimers Dis. 2018; 64(Suppl 1): S47–S105. doi: 10.3233/JAD-179932

PMCID:: PMC6008221

Abstract Article PDF–2.2M

Select item 723078017.

Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease

Rohith N Thota, Jessica I Rosato, Cintia B Dias, Tracy L Burrows, Ralph N Martins, Manohar L Garg

Nutrients. 2020 Apr; 12(4): 1032. Published online 2020 Apr 9. doi: 10.3390/nu12041032

PMCID:: PMC7230780

Abstract Article PDF–1009K

Select item 603233318.

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

Panchanan Maiti, Gary L. Dunbar

Int J Mol Sci. 2018 Jun; 19(6): 1637. Published online 2018 May 31. doi: 10.3390/ijms19061637

PMCID:: PMC6032333

Abstract Article PDF–21M

Select item 769861019.

Curcumin Formulations and Trials: What’s New in Neurological Diseases

Stella Gagliardi, Carlo Morasso, Polychronis Stivaktakis, Cecilia Pandini, Veronica Tinelli, Aristides Tsatsakis, Davide Prosperi, Miriam Hickey, Fabio Corsi, Cristina Cereda

Molecules. 2020 Nov; 25(22): 5389. Published online 2020 Nov 18. doi: 10.3390/molecules25225389

PMCID:: PMC7698610

Abstract Article PDF–291K

Select item 1112084220.

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

Shengchun Lou, Danfeng Gong, Mengting Yang, Qing Qiu, Jialie Luo, Tingting Chen

Int J Mol Sci. 2024 May; 25(10): 5123. Published online 2024 May 8. doi: 10.3390/ijms25105123

PMCID:: PMC11120842

Abstract Article PDF–19M

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Figure 2

Curcumin: a pleiotropic agent for treatment of Alzheimer's disease.
Curcumin decreases Aβ production, inhibits Aβ aggregation, and promotes Aβ clearance. Besides, curcumin inhibits inflammatory signal pathways and decreases the production of inflammatory cytokines. Additionally, curcumin reduces oxidative stress and scavenge radicals. Aβ: Amyloid β-protein.

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

Neural Regen Res. 2018 Apr;13(4):742-752.
Figure 6

The mechanism of action of curcumin nanoformulations in Alzheimer's disease

A New Perspective on the Treatment of Alzheimer's Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Oxid Med Cell Longev. 2022;2022:6168199.
Figure 5

Carriers used for the delivery of curcumin for Alzheimer’s treatment for in vivo studies [,,,,,,,].

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Materials (Basel). 2021 Jun;14(12):3332.
Figure 4

Interaction of curcumin with the Aβ fibril at a lower concentration of curcumin. Curcumin is represented as line structure in red. (a) Illustration showing the binding of curcumin with the Aβ fibril in the following three modes: (1 and 3) curcumin parallel to the β-strands (BE = −30 and −25 kcal mol^–1, respectively), (2) curcumin interacting with the loop region between the β-strands parallel to the fibril axis (BE = 26 kcal mol^–1), and (4) curcumin going into the core of the fibril (BE = −27 kcal mol^–1). (b) Top view of curcumin entering the central cavity. (c) The G33XXXG37 motif showing the main residues involved in binding with curcumin.

Toward the Noninvasive Diagnosis of Alzheimer’s Disease: Molecular Basis for the Specificity of Curcumin for Fibrillar Amyloid-β

ACS Omega. 2022 Jun 28;7(25):22032-22038.