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1.
Figure 4

Figure 4. Correlation between NAD+ levels and Age in (A) Males (B) Females.. From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

(A) NAD+ concentrations decline with age in males. NAD+ levels decreased significantly in males aged between 0–77 years (line a; p = 0.0007; n = 27). Pearson's correlation coefficient for a normally distributed population, r = −0.769. The post-pubescent data for male subjects also showed a decline in NAD+ levels with age (line b; r = −0.706; p = 0.0001; n = 19). An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) NAD+ concentrations decreased significantly with age (36–76) in post-pubescent females (p = 0.01; n = 22). Pearson's correlation coefficient for a normally distributed population,r = −0.537. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

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2.
Figure 6

Figure 6. (A) Lipid peroxidation increases significantly in parallel to increased DNA damage in post pubescent males (p<0.0001). . From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

The subjects were aged between 15–77 years (n = 19). Spearman's correlation coefficient, r = 0.7209. An exponential (first-order) least squares fit was used to generate the nonlinear trend line. (B) PARP activity decreases in line with a decline in NAD+ levels in post pubescent male subjects (p = 0.0149). . The subjects were aged between 15–77 years (n = 19). Pearson's correlation coefficient,r = −0.5491 An exponential (first-order) least squares fit was used to generate the nonlinear trend line. (C) Correlation between NAD+ levels and SIRT1 activity in post pubescent male subjects. The subjects were aged between 15–77 years (n = 19). The correlation is not of statistical significance (p = 0.9829). Pearson's correlation coefficient,r = −0.005263.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

CitationFull text

3.
Figure 2

Figure 2. Correlation between Phosphorylation of H2AX at Ser139 and age in both (A) Males (B) Females.. From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

(A) Phosphorylated-H2AX as a marker for DNA damage in male subjects show a significant correlation with age. Line a represents the correlation for subjects aged between 0–77 years (p = 0.0095; n = 27). Line b shows post-pubescent data (males only) (p = 0.0286; n = 19). Pearson's Correlation coefficient for normally distributed data was r = 0.490 and r = 0.502 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Phosphorylated-H2AX as a marker for DNA damage in post-pubescent female subjects shows a significant positive correlation with age (36–76 years) (p = 0.003; n = 22). Pearson's Correlation coefficient for a normally distributed population was r = 0.600. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

CitationFull text

4.
Figure 5

Figure 5. Correlation between SIRT1 Activity and Age in (A) Males (B) Females.. From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

(A) SIRT1 activity declines with age in post-pubescent males. The apparent negative correlation in SIRT1 activity with age in males aged between 0–77 years was not statistically significant (line a; p = 0.0385; n = 27). Spearman's correlation coefficient for a non-normally distributed population, r = −0.400. Line b represents the post-pubescent data shows a significant negative correlation with age (r = −0.612; p = 0.007; n = 19). An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Changes in SIRT1 with age in females. The apparent increase in PARP activity with age (36–76 years) is not statistically significant (p = 0.3743; n = 22). Spearman's correlation coefficient for a non-normally distributed population,r = 0.194. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

CitationFull text

5.
Figure 3

Figure 3. Correlation between PARP activity and aging in (A) Males (B) Females.. From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

(A) PARP activity increases with age in male subjects. PARP activity increases significantly in male subjects aged between 0–77 years (line a; p<0.0001; n = 27). The data including the post-pubescent subjects (males only) shows no significant change in PARP activity with age (line b; p = 0.0913; n = 19). Pearson's correlation coefficient was a normally distributed population was r = 0.768 and r = 0.399 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) PARP activity with age in female subjects (n = 27). The apparent increase in PARP activity with age (36–76 years) is not statistically significant in post-pubescent female subjects (p = 0.4390; n = 22). Spearman's Correlation coefficient for a non-normally distributed population was r = 0.174. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

CitationFull text

6.
Figure 1

Figure 1. Effect of age on tissue lipid peroxidation in (A) males (B) females.. From: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue.

(A) Lipid peroxidation increases with age in male subjects. MDA levels in human tissue increased significantly with age in males aged between 0–77 years (Line a; p = 0.0003; n = 27). Line b shows post-pubescent (males only) data (p = 0.0044; n = 19). Spearman's correlation coefficient for the non-normally distributed population was r = 0.643 and r = 0.623 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Changes in lipid peroxidation with age in female subjects. The apparent increase in MDA levels in post-pubescent females (36–76 years) is not statistically significant (p = 0.3734; n = 22). Spearman's Correlation coefficient for a non-normally distributed population was 0.200. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.

Hassina Massudi, et al. PLoS One. 2012;7(7):e42357.

CitationFull text

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