Meclizine hydrochloride - PMC

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Did you mean: buclizine hydrochloride (93 items)

Select item 103326021.

Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Yasunari Kamiya, Daisaku Kato, Genta Takemoto, Kenta Sawamura, Shinji Ueno, Nakai Yasuhiro, Kazuki Nishida, Shiro Imagama

PLoS One. 2023; 18(7): e0283425. Published online 2023 Jul 10. doi: 10.1371/journal.pone.0283425

PMCID:: PMC10332602

Abstract Article PDF–1.4M

Select item 71538852.

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Hiroshi Kitoh, Masaki Matsushita, Kenichi Mishima, Tadashi Nagata, Yasunari Kamiya, Kohei Ueda, Yachiyo Kuwatsuka, Hiroshi Morikawa, Yasuhiro Nakai, Naoki Ishiguro

PLoS One. 2020; 15(4): e0229639. Published online 2020 Apr 13. doi: 10.1371/journal.pone.0229639

PMCID:: PMC7153885

Abstract Article PDF–1.1M

Select item 74847963.

QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC-Fluorescence detection method

Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Iqbal Nasiri, Kamran Ahmed, Iyad Naeem Muhammad, Farrukh Rafiq Ahmed

Sci Rep. 2020; 10: 14765. Published online 2020 Sep 10. doi: 10.1038/s41598-020-71751-y

PMCID:: PMC7484796

Abstract Article PDF–5.5M

Select item 53891044.

Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent—Meclizine HCl

Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Muhammad Iqbal Nasiri, Kamran Ahmed, Mansoor Ahmad

Lipids Health Dis. 2017; 16: 75. Published online 2017 Apr 12. doi: 10.1186/s12944-017-0466-x

PMCID:: PMC5389104

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Select item 73737085.

The effects of meclizine on motion sickness revisited

Tobias Wibble, Johanna Engström, Luca Verrecchia, Tony Pansell

Br J Clin Pharmacol. 2020 Aug; 86(8): 1510–1518. Published online 2020 Mar 3. doi: 10.1111/bcp.14257

PMCID:: PMC7373708

Abstract Article PDF–761K

Select item 106632436.

Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway

Rasha E. Mostafa, Gihan F. Asaad

Metab Brain Dis. 2023; 38(8): 2797–2806. Published online 2023 Sep 21. doi: 10.1007/s11011-023-01295-3

PMCID:: PMC10663243

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Select item 94280997.

Formulation and in-silico study of meclizine ointment as anti-eczema

Wafa M. Al-Madhagi, Abdulkarim K. Y. Alzomor, Nor Hisam Zamakshshari, Maria A. Mubarak

In Silico Pharmacol. 2022; 10(1): 15. Published online 2022 Aug 30. doi: 10.1007/s40203-022-00129-x

PMCID:: PMC9428099

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Select item 48975338.

Formulation Development and Characterization of Meclizine Hydrochloride Sublimated Fast Dissolving Tablets

Sateesh Kumar Vemula, Mohan Vangala

Int Sch Res Notices. 2014; 2014: 281376. Published online 2014 Aug 25. doi: 10.1155/2014/281376

PMCID:: PMC4897533

Abstract Article PDF–991K

Select item 104041539.

Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride

Wafa M. Al-Madhagi, Arwa Alshargabi, Abdulkarim K. Y. Alzomor, Olla Sharhan

Adv Pharmacol Pharm Sci. 2023; 2023: 5512379. Published online 2023 Jul 29. doi: 10.1155/2023/5512379

PMCID:: PMC10404153

Abstract Article PDF–228K

Select item 160311110.

Meclizine in pregnancy in relation to congenital malformations.

S Shapiro, D W Kaufman, L Rosenberg, D Slone, R R Monson, V Siskind, O P Heinonen

Br Med J. 1978 Feb 25; 1(6111): 483. doi: 10.1136/bmj.1.6111.483

PMCID:: PMC1603111

Summary Page Browse PDF–225K

Select item 1060957311.

Comparative Study of Augmented Classical Least Squares Models for UV Assay of Co-Formulated Antiemetics Together with Related Impurities

Muneera S. M. Al-Saleem, Hany W. Darwish, Ibrahim A. Naguib, Mohammed E. Draz

Molecules. 2023 Oct; 28(20): 7044. Published online 2023 Oct 12. doi: 10.3390/molecules28207044

PMCID:: PMC10609573

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Select item 598116212.

Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

Lucas N. Alberca, María L. Sbaraglini, Juan F. Morales, Roque Dietrich, María D. Ruiz, Agustina M. Pino Martínez, Cristian G. Miranda, Laura Fraccaroli, Catalina D. Alba Soto, Carolina Carrillo, Pablo H. Palestro, Alan Talevi

Front Cell Infect Microbiol. 2018; 8: 173. Published online 2018 May 25. doi: 10.3389/fcimb.2018.00173

PMCID:: PMC5981162

Abstract Article PDF–3.3M

Select item 951471713.

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

Hany Ibrahim, Omar M El-Abassy, Hisham Ezzat Abdellatef, Hassan A. M. Hendawy, Heba M El-Sayed

BMC Chem. 2022 Dec; 16(1): 72. Published online 2022 Sep 27. doi: 10.1186/s13065-022-00860-8

PMCID:: PMC9514717

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Select item 467465114.

Dissolution Testing for Bioavailability of Over-the-Counter (OTC) Drugs—a Technical Note

Zongming Gao, Lawrence Yu, Stephanie Clark, Mike Trehy, Terry Moore, Benjamin Westenberger, Lucinda Buhse, John Kauffman, Benjamin Bishop, Lydia Velazquez, Scott Furness

AAPS PharmSciTech. 2015 Oct; 16(5): 1227–1233. Published online 2015 Feb 14. doi: 10.1208/s12249-015-0297-x

PMCID:: PMC4674651

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Select item 847668015.

Effects of Several Therapeutic Agents on Mammalian Vestibular Function: Meclizine, Diazepam, and JNJ7777120

Choongheon Lee, Timothy A. Jones

J Assoc Res Otolaryngol. 2021 Oct; 22(5): 527–549. Published online 2021 May 19. doi: 10.1007/s10162-021-00803-5

PMCID:: PMC8476680

Abstract Article PDF–3.8M

Select item 708544716.

The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy

Yuan Guan, Xinyu Chen, Manhong Wu, Wan Zhu, Ahmed Arslan, Saori Takeda, Mindie H. Nguyen, Ravindra Majeti, Dan Thomas, Ming Zheng, Gary Peltz

J Hepatol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: J Hepatol. 2020 Apr; 72(4): 746–760. Published online 2019 Nov 22. doi: 10.1016/j.jhep.2019.11.007

PMCID:: PMC7085447

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Select item 192674317.

Meclozine (“ Ancoloxin ”) and Foetal Abnormalities

G. I. Watson

Br Med J. 1962 Dec 1; 2(5317): 1446. doi: 10.1136/bmj.2.5317.1446

PMCID:: PMC1926743

Summary Page Browse PDF–230K

Select item 103822118.

Effects of Hyoscine and Meclozine on Vigilance and Short-term Memory

W. P. Colquhoun

Br J Ind Med. 1962 Oct; 19(4): 287–296. doi: 10.1136/oem.19.4.287

PMCID:: PMC1038221

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Select item 553810819.

Augmentation of Glycolytic Metabolism by Meclizine is Indispensable for Protection of Dorsal Root Ganglion Neurons from Hypoxia-Induced Mitochondrial Compromise

Ming Zhuo, Murat F. Gorgun, Ella W. Englander

Free Radic Biol Med. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2016 Oct; 99: 20–31. Published online 2016 Jul 22. doi: 10.1016/j.freeradbiomed.2016.07.022

PMCID:: PMC5538108

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Select item 485710920.

Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

Chien Tai Hong, Kai-Yin Chau, Anthony H. V. Schapira

Sci Rep. 2016; 6: 25344. Published online 2016 May 5. doi: 10.1038/srep25344

PMCID:: PMC4857109

Abstract Article PDF–842K

Did you mean: buclizine hydrochloride (93 items)

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Fig 2Plasma concentration of meclizine from pre-dosing to 24 hours after single oral administration of meclizine hydrochloride 25 mg tablet.

Individual plasma concentration profiles of meclizine in ACH children (A) and body weight normalized profiles by the mean body weight of MEC-01 to MEC-06 (22.9 kg) (B).

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

PLoS One. 2020;15(4):e0229639.
Fig 3Plasma concentration of meclizine from pre-dosing to 24 hours after twice a day oral administration of meclizine hydrochloride 25 mg tablet.

Individual plasma concentration profiles of meclizine in ACH children (A) and body weight normalized profiles by the mean body weight of MEC-01 to MEC-06 (22.9 kg) (B).

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

PLoS One. 2020;15(4):e0229639.
Fig 5Simulated plasma concentration profile of meclizine at twice a day for 14 days multiple administrations in ACH children.

Plasma concentration simulated using the mean measured results after once a day administration of meclizine hydrochloride 25 mg tablet (body weight normalized) also reached steady state around 10 days after the first dose.

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

PLoS One. 2020;15(4):e0229639.
Fig 4Simulated plasma concentration profile of meclizine at once a day for 14 days multiple administrations in ACH children.

Plasma concentration simulated using the mean measured results after once a day administration of meclizine hydrochloride 25 mg tablet (body weight normalized) apparently reached steady state around 10 days after the first dose.

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

PLoS One. 2020;15(4):e0229639.