PMC

Group (high vs. low) by condition (hypnosis vs. rest/memory in random order) differences in functional connectivity during hypnosis between left and right DLPFC and ipsilateral insular cortex and contralateral supramarginal gyrus. Seeds displayed in red. (A) Left DLPFC, Group by condition interaction (upper panel): orange–yellow regions show significantly increased functional connectivity to left DLPFC during hypnosis relative to rest, for highs but not lows. The effect is not significant for memory relative to rest at the same threshold. Hypnosis versus rest within highs (lower panel): orange–yellow regions confirm significantly increased FC to left DLPFC during hypnosis relative to rest for highs alone. The effect is not significant for memory relative to rest at the same threshold. The two hypnosis conditions are not significantly different. Mean z scores extracted from significant left insula cluster are displayed across group and condition (right panel). (B) Right DLPFC, Hypnosis versus rest within highs: orange–yellow regions show significantly increased FC to right DLPFC during hypnosis relative to rest for highs alone. Also, regions in the paracingulate gyrus and left insula showed significantly greater connectivity with right DLPFC in highs relative to lows. (C) Hypnotic response scores correlating with FC: orange–yellow regions (insular cortex and supramarginal gyrus) show increased FC to left DLPFC during hypnosis. For PCC and dACC seeds, no regions in the group by condition comparison survived correction, so no further tests were performed.

Mean positive beleifs about hypnosis subscale score by past experience with hypnosis. HE- = no past experience with hypnosis, HE+ = past experience with hypnosis.

Mean total attitude towards hypnosis (ATH) score by past experience with hypnosis. HE- = no past experience with hypnosis, HE+ = past experience with hypnosis.

fALFF activity in the dACC. Group (high vs. low hypnotizable) by condition (rest/memory vs. hypnosis in random order) differences in dACC activity. Images are displayed in radiologic convention: the left side of the image corresponds to the right side of the brain. (A) Group by condition interaction (upper panel): blue regions show an interaction between group (high vs. low) and condition (hypnosis vs. rest). The interaction is N.S. for memory relative to rest at the same threshold. The two hypnosis conditions do not show significantly different fALFF. Mean z scores extracted from significant dACC cluster are plotted across group and condition (right panel). Hypnosis versus rest within highs (lower panel): blue regions confirm significantly decreased fractional amplitude during hypnosis relative to rest only for highs. The effect is not significant for memory relative to rest at the same threshold. (B) Hypnotic response scores correlate with fALFF: blue regions show decreasing fractional amplitude during hypnosis relative to rest as post-scan intensity of hypnosis ratings increases, among all 36 highs. Scatterplot shows individual mean z scores extracted from the significant dACC region against individual mean intensity of hypnosis ratings.