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PubChem BioAssay

Biological Activity

Links from PubChem BioAssay

Items: 1 to 20 of 3852

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Select item 12594041.

qHTS assay to identify small molecule agonists of the estrogen related receptor (ERR) signaling pathway from Tox21 library: Summary

Source:: Tox21

Protein Target:: estrogen-related nuclear receptor alpha [Homo sapiens]

Assay data:309 Active, 9667 Tested

AID:: 1259404

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 12594032.

qHTS assay to identify small molecule antagonists of the estrogen related receptor (ERR) signaling pathway from Tox21 library: Summary

Source:: Tox21

Protein Target:: estrogen-related nuclear receptor alpha [Homo sapiens]

Assay data:807 Active, 131 Activity ≤ 1 µM, 9667 Tested

AID:: 1259403

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 12594023.

qHTS assay to identify small molecule agonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library: Summary

Source:: Tox21

Protein Target:: estrogen-related nuclear receptor alpha [Homo sapiens]

Assay data:390 Active, 9667 Tested

AID:: 1259402

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 12594014.

qHTS assay to identify small molecule antagonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library: Summary

Source:: Tox21

Protein Target:: estrogen-related nuclear receptor alpha [Homo sapiens]

Assay data:462 Active, 149 Activity ≤ 1 µM, 9667 Tested

AID:: 1259401

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 12594005.

qHTS Assay for Antagonists of the Relaxin Receptor RXFP1

Source:: NCGC

Protein Target:: Relaxin receptor 1; Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1

Assay data:2064 Active, 352386 Tested

AID:: 1259400

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 12593966.

qHTS assay to identify small molecule antagonists of the estrogen receptor beta (ER-beta) signaling pathway: Summary

Source:: Tox21

Protein Target:: estrogen receptor 2 (ER beta) [Homo sapiens]

Assay data:593 Active, 9667 Tested

AID:: 1259396

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 12593957.

qHTS assay to identify small molecule antagonists of the thyroid stimulating hormone receptor (TSHR) signaling pathway: Summary

Source:: Tox21

Protein Target:: thyroid stimulating hormone receptor [Homo sapiens]

Assay data:316 Active, 6 Activity ≤ 1 µM, 9667 Tested

AID:: 1259395

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 12593928.

qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway: Summary

Source:: Tox21

Protein Target:: GLI family zinc finger 3 [Homo sapiens]

Assay data:1156 Active, 2 Activity ≤ 1 nM, 322 Activity ≤ 1 µM, 9667 Tested

AID:: 1259392

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 12593889.

qHTS assay to identify small molecule HDAC inhibitors: Summary

Source:: Tox21

Protein Target:: histone deacetylase 9 isoform 3 [Homo sapiens]

Assay data:421 Active, 16 Activity ≤ 1 µM, 9667 Tested

AID:: 1259388

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125938710.

qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway in the presence of an antagonist: Summary

Source:: Tox21

Protein Target:: AR protein [Homo sapiens]

Assay data:332 Active, 9667 Tested

AID:: 1259387

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 125938611.

qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway in the presence of an antagonist - cell viability counter screen

Source:: Tox21

Assay data:564 Active, 27 Activity ≤ 1 µM, 9667 Tested

AID:: 1259386

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125938212.

qHTS assay to identify small molecule antagonists of the estrogen receptor beta (ER-beta) signaling pathway - cell viability counter screen

Source:: Tox21

Assay data:562 Active, 40 Activity ≤ 1 µM, 9667 Tested

AID:: 1259382

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125938113.

qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway in the presence of an antagonist

Source:: Tox21

Protein Target:: AR protein [Homo sapiens]

Assay data:382 Active, 2 Activity ≤ 1 nM, 175 Activity ≤ 1 µM, 9667 Tested

AID:: 1259381

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 125938014.

qHTS assay to identify small molecule agonists of the estrogen receptor beta (ER-beta) signaling pathway - cell viability counter screen

Source:: Tox21

Assay data:1136 Active, 121 Activity ≤ 1 µM, 9667 Tested

AID:: 1259380

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125937915.

qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway in the presence of an antagonist - cell viability counter screen

Source:: Tox21

Assay data:756 Active, 46 Activity ≤ 1 µM, 9667 Tested

AID:: 1259379

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125937816.

qHTS assay to identify small molecule antagonists of the estrogen receptor beta (ER-beta) signaling pathway

Source:: Tox21

Protein Target:: estrogen receptor 2 (ER beta) [Homo sapiens]

Assay data:464 Active, 1 Activity ≤ 1 nM, 65 Activity ≤ 1 µM, 9667 Tested

AID:: 1259378

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125937017.

Inhibitors of CDC25B-CDK2/CyclinA interaction

Source:: Center for Chemical Genomics, University of Michigan

Protein Targets:: CDC25B protein [Homo sapiens]; ...
Total:: 3

Assay data:680 Active, 93851 Tested

AID:: 1259370

Summary Compounds, Active Related BioAssays by Target

Select item 125936918.

qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway

Source:: Tox21

Protein Target:: GLI family zinc finger 3 [Homo sapiens]

Assay data:1356 Active, 2 Activity ≤ 1 nM, 487 Activity ≤ 1 µM, 9667 Tested

AID:: 1259369

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125936819.

qHTS assay to identify small molecule agonists of the sonic hedgehog signaling (Shh) pathway

Source:: Tox21

Protein Target:: GLI family zinc finger 3 [Homo sapiens]

Assay data:58 Active, 30 Activity ≤ 1 µM, 9667 Tested

AID:: 1259368

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 125936720.

qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway - cell viability counter screen

Source:: Tox21

Assay data:714 Active, 57 Activity ≤ 1 µM, 9667 Tested

AID:: 1259367

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

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Target

Proteins (1,728)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (5)
BioAssays with compounds reported as validated chemical probes
BioActivity Analysis of reported chemical probes

Active Compounds (3,848)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (397)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (1,961)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (50)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2,426)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (895)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
On Hold (1)
On hold BioAssays

Assay Project (1,907)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (954)
BioAssays extracted from the literature
NIH MLP (2,077)
BioAssays deposited by the NIH Molecular Libraries Program
Other (664)
BioAssays deposited by other experimentalists

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