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UV-Thermal Melt from Article 10.1021/jm030121k: "Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)."
Assay data:9 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Exchange Curve Assay from Article 10.1021/jm030120s: "Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors."
Assay data:9 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorescence Exchange Curve Assay from Article 10.1038/nsb770: "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site."
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of SKF-86002 binding to human inactive p38alpha after 60 mins by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysis
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of p38alpha (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation
Assay data:57 Activity ≤ 1 nM, 344 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Binding affinity to p38alpha MAPK by surface plasmon resonance method
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Binding constant for p38-alpha kinase domain
Assay data:10 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 72 Tested
Binding affinity to full-length GST-tagged p38alpha by surface plasmon resonance assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of p38V kinase stie 3 delta 296-301 mutant
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of p38alpha
Binding constant for full-length p38-alpha
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 38 Tested
Binding affinity to p38alpha by exchange curve binding kinetic analysis
Average Binding Constant for p38-alpha; NA=Not Active at 10 uM
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 20 Tested
Kd value and murine Mitogen-activated protein kinase p38 alpha complex was calculated
Assay data:27 Active, 11 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 27 Tested
Binding affinity for Mitogen-activated protein kinase p38 alpha
Assay data:17 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 17 Tested
Dissociation constant at Tref against human Mitogen-activated protein kinase p38 alpha
Assay data:10 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 10 Tested
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