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Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay
Assay data:24 Active, 20 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay
Assay data:26 Active, 2 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 31 Tested
Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay
Assay data:26 Active, 17 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 31 Tested
Agonist activity at human MC1R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay
Assay data:26 Active, 18 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 31 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:31 Active, 1 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 31 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:28 Active, 1 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 31 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:31 Active, 11 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay
Assay data:28 Active, 12 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:27 Active, 19 Activity ≤ 1 µM, 28 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:27 Active, 27 Activity ≤ 1 µM, 28 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:26 Active, 23 Activity ≤ 1 µM, 28 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay
Assay data:28 Active, 7 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay
Assay data:27 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 28 Tested
Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay
Assay data:28 Active, 3 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Agonist activity at human melanocortin receptor 1 expressed in human T-Rex-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay
Assay data:27 Active, 19 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HTRF method
Assay data:19 Active, 3 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 21 Tested
Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method
Assay data:13 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 18 Tested
Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method
Assay data:17 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 19 Tested
Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method
Assay data:20 Active, 6 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 21 Tested
Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay
Assay data:14 Active, 10 Activity ≤ 1 µM, 21 Tested
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