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Inhibition of Mycobacterium smegmatis ATP synthase
Assay data:18 Active, 4 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in human A-THP1 macrophages assessed as viability of infected macrophages incubated for 96 hrs by fluorescence microplate assay
Assay data:7 Active, 5 Activity ≤ 1 µM, 10 Tested
Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate HD5 assessed as inhibition of bacterial growth incubated for 7 days by by microplate alamar blue assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested
Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate HD4 assessed as inhibition of bacterial growth incubated for 7 days by by microplate alamar blue assay
Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate HD3 assessed as inhibition of bacterial growth incubated for 7 days by by microplate alamar blue assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate HD2 assessed as inhibition of bacterial growth incubated for 7 days by by microplate alamar blue assay
Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate HD1 assessed as inhibition of bacterial growth incubated for 7 days by by microplate alamar blue assay
Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth
Assay data:32 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 37 Tested
Cmax in Sprague-Dawley rat at 5 mg/kg,po
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Cmax in mouse at 6.25 mg/kg,po
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antitubercular activity against Mycobacterium tuberculosis mc2 6230 assessed as inhibition of bacterial growth incubated for 7 days
Assay data:8 Active, 2 Activity ≤ 1 µM, 37 Tested
Antitubercular activity against Mycobacterium tuberculosis H37Rv by broth microdilution method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition incubated for 5 days by resazurin microtiter assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 21 Tested
Inhibition of cytochrome-bd oxidase in Mycobacterium tuberculosis clinical isolate N0145 assessed as replicating ATP by measuring ATP depletion incubated for 15 hrs in absence of Q203 by BacTiter-Glo luminescence assay
Assay data:1 Active, 16 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of human ERG
Assay data:13 Active, 42 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:1774 Active, 1 Activity ≤ 1 nM, 362 Activity ≤ 1 µM, 5242 Tested
SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate
Assay data:109 Active, 61 Activity ≤ 1 µM, 109 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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