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Human GPR183 (Class A Orphans)
Assay data:8 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
Assay data:31 Active, 10 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of 25-[3H]hydroxycholesterol from GST-tagged ROR gamma ligand binding domain (unknown origin) expressed in Escherichia coli BL21 gold (DE3) cells by radioligand competition assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of 25-[3H]hydroxycholesterol from GST-tagged ROR alpha ligand binding domain (unknown origin) expressed in Escherichia coli BL21 gold (DE3) cells by radioligand competition assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Cytotoxicity against mouse 158N cells assessed as cell viability after 24 hrs by trypan blue-based cell counting method
Assay data:3 Tested
SummaryPubMed Citation
Growth inhibition of mouse 158N cells after 24 hrs by trypan blue-based cell counting method
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Cytotoxicity against rat C6 cells assessed as cell viability after 24 hrs by trypan blue-based cell counting method
Growth inhibition of rat C6 cells after 24 hrs by trypan blue-based cell counting method
Cytotoxicity against human SK-N-BE cells assessed as cell viability after 24 hrs by trypan blue-based cell counting method
Assay data:5 Tested
Growth inhibition of human SK-N-BE cells after 24 hrs by trypan blue-based cell counting method
Cytotoxicity against BALB/cJRj mouse astrocytes/oligodendrocytes assessed as cell viability at 50 uM after 24 hrs by trypan blue-based cell counting method
Growth inhibition of BALB/cJRj mouse astrocytes/oligodendrocytes at 50 uM after 24 hrs by trypan blue-based cell counting method
Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis
Assay data:20 Active, 2 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Selectivity ratio of agonist activity at Hh receptor over agonist activity at LXR in mouse C3H10T1/2 cells
Assay data:10 Tested
Agonist activity at LXR in mouse C3H10T1/2 cells assessed as fold increase in ABCA1 expression at 5 uM by RT-PCR analysis relative to control
Assay data:13 Tested
Agonist activity at Hh receptor in mouse C3H10T1/2 cells assessed as fold increase in Gli1 expression at 5 uM by RT-PCR analysis relative to control
Selectivity index, ratio of IC50 for human ARPE19 cells to IC50 for human HT-29 cells
Assay data:23 Tested
Cytotoxicity against human BJ cells assessed as cell viability after 48 hrs by alamar blue assay
Assay data:1 Active, 9 Tested
Cytotoxicity against human ARPE19 cells assessed as cell viability after 48 hrs by alamar blue assay
Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by alamar blue assay
Assay data:1 Active, 11 Tested
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