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Items: 1 to 20 of 175

2.

Integrin alpha-5/beta-1 antagonist

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
3.

Binding affinity to alpha5beta1 integrin (unknown origin)

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
4.

Inhibition of fibronectin binding to human alpha5beta1 integrin after 1 hr by ELISA

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
5.

Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion at 10 ug/ml after 30 mins by fluorescence assay in presence of neutralizing antibody of beta1

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
6.

Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of cell adhesion after 30 mins by fluorescence assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
7.

Antagonist activity at alpha4beta1 integrin in human Jurkat E6.1 cells assessed as inhibition of VCAM1-mediated cell adhesion after 30 mins by fluorescence assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d; ...
Total:
2
8.

Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
9.

Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
10.

Inhibition of fibronectin binding to human alpha5beta1 integrin receptor after 1 hr by competitive solid-phase binding ELISA

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
11.

Antagonist activity at integrin alpha4beta1 receptor in human CCRF-CEM cells assessed as detachment of adherent cell from fibronectin at 1 to 500 uM after 24 to 48 hrs by MTT assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d; ...
Total:
2
12.

Antagonist activity at integrin alpha4beta1 receptor in human CCRF-CEM cells assessed as inhibition of cell adhesion to fibronectin after 1 hr by calcein AM staining-based fluorescence assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d; ...
Total:
2
13.

Binding affinity to alpha2beta1 integrin (unknown origin)

Source:
ChEMBL
Protein Targets:
Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen=CD49b; ...
Total:
2
14.

Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d; ...
Total:
2
15.

Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1

Source:
ChEMBL
Protein Targets:
Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d; ...
Total:
2
16.

Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen type-1 after 3 hrs by solid phase ELISA-type assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen=CD49b; ...
Total:
2
17.

Antagonist activity at integrin alpha1beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen type-1 after 3 hrs by solid phase ELISA-type assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen=CD49a; ...
Total:
2
18.

Antagonist activity at integrin alpha5beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen type-1 after 3 hrs by solid phase ELISA-type assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
19.

Binding affinity to soluble truncated human recombinant 6His-tagged alpha5beta1 and integrins were expressed in HEK293T cells after 2 hrs by competition ELISA-like assay

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
20.

Inhibition of alpha5beta1 integrin-mediated human K562 cell adhesion to fibronectin incubated for 30 mins before plating measured after 1 hr

Source:
ChEMBL
Protein Targets:
Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen=CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ...
Total:
2
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