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Items: 1 to 20 of 558

1.

Induction of Nrf2 nuclear translocation in BaP-treated neonatal HDF assessed as upregulation of NQO1 mRNA expression at 10 uM after 24 hrs by real-time PCR analysis relative to BaP-treated control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
2.

Induction of Nrf2 nuclear translocation in BaP-treated neonatal HDF at 10 uM after 2 hrs by DAPI staining-based confocal scanning laser microcopic analysis in presence of PI3K/Akt inhibitor LY294002

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
3.

Induction of Nrf2 nuclear translocation in neonatal HDF at 10 uM after 2 hrs by DAPI staining-based confocal scanning laser microcopic analysis

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
4.

Induction of Nrf2 nuclear translocation in BaP-treated neonatal HDF at 10 uM after 2 hrs by DAPI staining-based confocal scanning laser microcopic analysis

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
5.

Activation of NRF2 in human HaCaT cells expressing rat NQO1 assessed as induction of NQO1 expression at 50 nM to 5 uM incubated for 24 hrs by ARE-driven luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
6.

Keap1/Nrf2 inhibitor

Source:
ChEMBL
Protein Targets:
Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19; ...
Total:
2
7.

Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinone

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
8.

Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotropy assay

Source:
ChEMBL
Protein Targets:
Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19; ...
Total:
2
9.

Activation of Nrf2 (unknown origin) expressed in CHO-ARE luc cells at 10 to 30 uM after 18 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
10.

Activation of Nrf2 (unknown origin) expressed in CHO-ARE luc cells at 10 uM after 18 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
11.

Activation of Nrf2 (unknown origin) expressed in CHO-ARE luc cells at 5.2 uM after 18 hrs by luciferase reporter gene assay relative to vehicle-treated control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
12.

Activation of Nrf2 (unknown origin) expressed in CHO-ARE-Luc cells after 18 hrs by luciferase reporter gene assay in presence of GSH

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
13.

Activation of Nrf2 in human VSMC assessed as induction of HO-1 expression at 3 uM after 18 hrs by immunoblotting analysis

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
14.

Activation of Nrf2 (unknown origin) expressed in CHO-ARE-Luc cells after 18 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
15.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 0.01 uM after 12 hrs by luciferase reporter gene assay relative to control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
16.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 0.1 uM after 12 hrs by luciferase reporter gene assay relative to control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
17.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 1 uM after 12 hrs by luciferase reporter gene assay relative to control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
18.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 5 uM after 12 hrs by luciferase reporter gene assay relative to control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
19.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells at 10 uM after 12 hrs by luciferase reporter gene assay relative to control

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
20.

Induction of Nrf2-mediated ARE activity in human HepG2-ARE-C8 cells after 12 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
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