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Inhibition Assay from US Patent US9149492: "Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease"
Assay data:8 Active, 8 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ACAT-1 Enzyme Inhibition Assay from Article 10.1021/jm801507v: "Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor."
Assay data:1 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Effect on ACAT2 Activity from US Patent US10278962: "Tricyclic analogues, preparation method and uses thereof"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in adiponectin expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in hydroxy-steroid (17-beta) dehydrogenase 4 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in carnitine O-acetyltransferase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in acetyl-CoA acyltransferase 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in hydroxyacyl-CoA dehydrogenase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in enoyl CoA hydratase short chain 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in Acyl-CoA dehydrogenase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in FAS expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in Acyl-CoA synthetase long-chain family member 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in accumulation of fluorescence-labeled CE by 25-NBD cholesterol based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human SOAT1-mediated [14C]Cholesterol ester biosynthesis in CHO microsomal fraction after 5 mins in presence of [1-14C]oleoyl-CoA by TLC analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human SOAT1 mediated [14C]Cholesterol ester synthesis in CHO cells after 6 hrs in presence of [14C]Oleic acid by TLC analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ACAT1 in human HepG2 cells using cholesterol as substrate incubated for 9 hrs by fluorescence based cholesterol oxidase assay
Assay data:6 Tested
Inhibition of human ACAT1
Assay data:16 Active, 6 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SOAT1 in CHO cell microsomal fraction using [1-14C]oleoyl-CoA as substrate measured after 5 mins by TLC based method
Inhibition of African green monkey SOAT1 expressed in CHO cells using [1-14C]oleic acid incubated for 6 hrs by TLC based method
Assay data:1 Active, 6 Tested
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