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Items: 1 to 20 of 165

3.

Inhibition of mPGES1 isolated from human A549 cells at 10 uM after 15 mis by RP HPLC analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
4.

Inhibition of mPGES1 isolated from human A549 cells after 15 mis by RP HPLC analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
5.
6.
7.

Nuisance inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation at 0.1 to 10 uM pre-incubated for 15 mins using PGH2 substrate presence of triton X-100 by RP-HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
8.

Reversible inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation at 10 uM pre-incubated for 15 mins followed by 10 fold dilution using PGH2 substrate by RP-HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
9.

Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as remaining enzyme activity by measuring PGE2 formation at 10 uM incubated for 15 mins using PGH2 substrate by RP-HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
10.

Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using PGH2 substrate by RP-HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
AID:
1239703
11.

Inhibition of microsomal PGES-1 (unknown origin) up to 62.5 uM

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
12.

Binding affinity to mPGES-1 (unknown origin) assessed as increase in protein aggregation temperature at 0.1 mM by differential static light scattering method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
13.

Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
14.

Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
15.

Inhibition of human mPGES-1 by whole blood assay

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
16.

Inhibition of m-PGES1 in IL-1beta-induced human A549 cell microsomes assessed as reduction in 11beta-PGE2 production pre-incubated for 15 mins before PGH2 addition by UV detection based reverse-phase high-performance liquid chromatography

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
17.
18.

Inhibition of mPGES-1-mediated PGE2 formation in interleukin-1beta-stimulated human A549 microsomal membranes preincubated for 15 mins before PGH2 addition by RP-HPLC analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
19.

Inhibition of mPGES-1-mediated PGE2 formation in interleukin-1beta-stimulated human A549 microsomal membranes assessed as remaining activity at 10 uM preincubated for 15 mins before PGH2 addition by RP-HPLC analysis

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
20.

Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins in presence of PGH2 and glutathione by RP-HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
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