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Items: 1 to 20 of 1574

1.

Inhibition of COX2 (unknown origin) at 100 uM using arachidonic acid substrate by colorimetric assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
2.

Inhibition of COX2 (unknown origin) using arachidonic acid substrate by colorimetric assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
3.

Inhibition of COX2 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
4.

Inhibition of COX2 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
5.

Inhibition of COX2 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
6.

Inhibition of human recombinant COX-2 using arachidonic acid after 15 mins by fluorescence based assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
7.

Inhibition of COX2 in differentiated human THP1 cells assessed as induction of LPS-induced COX2 gene expression at 50 ug/ml preincubated for 1 hr followed by LPS induction measured after 3 hrs by real-time PCR analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
8.

Inhibition of human recombinant COX2 using arachidonic acid as substrate at 1 uM preincubated for 5 mins measured after 2 mins by colorimetric analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
9.

Inhibition of human recombinant COX2 assessed as reduction in 12-HHT formation pre-incubated for 5 mins before arachidonic acid addition by HPLC method

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
10.

Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha production at 10 uM by enzyme immunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
11.

Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resorufin after 5 mins by fluorescence based assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
12.

Inhibition of COX2 (unknown origin)

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
13.

Inhibition of COX2 (unknown origin) using arachidonic acid as substrate at 10 uM

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
14.

Competitive inhibition of human recombinant COX-2 using arachidonic acid as substrate by double reciprocal plot analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
15.

Binding affinity to human recombinant COX-2 assessed as binding constant at 10 uM by isothermal calorimetry

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
16.

Competitive inhibition of human recombinant COX-2 by UV-Visible spectrophotometry

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
17.

Competitive inhibition of human recombinant COX-2 assessed as association constant by UV-Visible spectrophotometry

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
18.

Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
19.

Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
20.

Inhibition of IL-1 beta-induced COX-2 activity in human SW982 cells assessed as enzyme activity at LD50 treated for 24 hrs prior to incubation with IL-1 beta for 6 hrs (Rvb = 100.0%)

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
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