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Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 using pNPP as substrate at 200 uM incubated for 10 mins by microplate reader based spectrophotometric analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Competitive inhibition of LMW-PTP (unknown origin) assessed as inhibition constant by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 using pNPP as substrate incubated for 10 mins by microplate reader based spectrophotometric analysis
Assay data:26 Active, 11 Activity ≤ 1 µM, 30 Tested
Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 at 10 uM using pNPP as substrate incubated for 10 mins by microplate reader based spectrophotometric analysis relative to control
Assay data:1 Active, 26 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N-terminal His-tagged full length mouse LMW-PTP expressed in Escherichia coli BL21(DE3) by SDS PAGE based mass spectrometry analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
LMPTP Primary Screening Protocol from US Patent US11220486: "Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof"
Assay data:261 Active, 51 Activity ≤ 1 µM, 333 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9522881: "Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
PTP pNPP Assay from US Patent US9217012: "Inhibitors of protein tyrosine phosphatases"
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of LMPTP in human HepG2 cells assessed as increase in insulin-stimulated AKT Thr308 phosphorylation at 500 nM preincubated overnight followed by insulin stimulation for 5 mins by Western blotting analysis
Assay data:1 Active, 1 Tested
Uncompetitive inhibition of recombinant human LMPTP-A using OMFP as substrate by Lineweaver-Burk plot analysis
Uncompetitive inhibition of recombinant human LMPTP-A using varying concentration of OMFP as substrate
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay
Assay data:19 Active, 16 Activity ≤ 1 µM, 24 Tested
Inhibition of LMW-PTP isoform A in human HepG2 cells assessed as increase in insulin-induced Akt phosphorylation at 16 uM pretreated for 2 hrs followed by insulin stimulation and measured after 30 mins by Western blot analysis relative to control
Inhibition of LMW-PTP isoform A in human HepG2 cells assessed as increase in insulin-induced Akt phosphorylation at 16 uM pretreated for 2 hrs followed by insulin stimulation and measured after 30 mins by Western blot analysis
Inhibition of LMW-PTP isoform A in human HepG2 cells assessed as increase in insulin-induced Akt phosphorylation pretreated for 2 hrs followed by insulin stimulation and measured after 30 mins by Western blot analysis
Competitive inhibition of LMW-PTP isoform B (unknown origin) using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis
Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate at 10 uM incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis relative to control
Assay data:8 Tested
Inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis
Assay data:18 Active, 33 Tested
Competitive inhibition of LMW-PTP isoform A (unknown origin)
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