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Items: 1 to 20 of 9736

1.

Binding affinity to LXR-beta ligand binding domain (unknown origin) by TR-FRET assay in presence of 0.1 uM agonist N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
2.

Antagonist activity at human LXR-beta transfected in HEK293 cells at 30 uM after 16 hrs by luciferase reporter gene assay in presence of 0.1 uM N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
3.

Antagonist activity at human LXR-beta transfected in HEK293 cells after 16 hrs by luciferase reporter gene assay in presence of 0.1 uM N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
4.

Agonist activity at human LXR-beta transfected in HEK293 cells after 16 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
5.

Agonist activity at human LXR-beta transfected in HEK293 cells at 30 uM after 16 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
6.

Transrepression activity of LXR in human THP1 cells assessed as inhibition of LPS-induced IL-6 level at 10 uM after 18 hrs by ELISA

Source:
ChEMBL
Protein Targets:
Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3; ...
Total:
2
7.

Agonist activity at GAL4-fused human LXRbeta expressed in HEK293 cells assessed as activation of basal transcriptional activity up to 10 uM after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
8.

Antagonist activity at GAL4-fused human LXRbeta expressed in HEK293 cells assessed as inhibition of T0901317-stimulated transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
9.

Agonist activity at human LXRbeta expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay relative to T0901317

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
10.

Agonist activity at human LXRbeta expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
11.

Agonist activity at Gal4 DNA binding domain-tagged human LXRbeta ligand binding domain expressed in HEK293 cells assessed as activation of receptor-mediated transcriptional activity by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
12.

Antagonist activity at Gal4 DNA binding domain-tagged human LXRbeta ligand binding domain expressed in HEK293 cells assessed as inhibition of receptor-mediated transcriptional activity by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
13.

Antagonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as inhibition of T0901317-induced basal transcriptional activity up to 10 uM after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
14.

Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
15.

Agonist activity at LXRbeta (unknown origin) expressed in CHOK1 cells at 10 uM incubated for 24 hrs by GAL4-responsive luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
16.

Agonist activity at LXRbeta (unknown origin) expressed in CHOK1 cells incubated for 24 hrs by GAL4-responsive luciferase reporter gene assay relative to 10 uM T0901317

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
17.

Agonist activity at LXRbeta (unknown origin) expressed in CHOK1 cells incubated for 24 hrs by GAL4-responsive luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
18.

Agonist activity at LXRbeta (unknown origin) relative to control

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
19.

Agonist activity at LXRbeta (unknown origin)

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
20.

Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
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