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Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/jm900135r: "Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6."
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Caspase Inhibition Assay from Article 10.1021/jm0506625: "N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies."
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Caspase Inhibition Assay from Article 10.1021/jm050896o: "Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors."
Assay data:51 Active, 49 Activity ≤ 1 µM, 51 Tested
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
Peptidase, CASP6 (Caspase 6) Eurofins-Panlabs enzyme assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Caspase-6 (h) Eurofins-Cerep enzyme and uptake assay
Assay data:1 Tested
CASPASE-6_CE Eurofins SafetyScreen44 (BI)
Inhibition of Caspase-6 (unknown origin) assessed as inhibition of release of AMC fluorescent product using Ac-VEID-AMC as substrate at 10 uM incubated for 30 mins by microplate reader relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Caspase 6 (unknown origin) at 10 uM
Assay data:3 Tested
Inhibition of caspase-6 (unknown origin) at 10 uM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of caspase6 (unknown origin) at 1 uM relative to control
Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent plate reader based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of caspase (unknown origin)
Inhibition of human recombinant caspase-6 using Ac-VEID-AMC as substrate at Km after 20 mins by fluorescence assay
Human Caspase 6 (C14: Caspase)
Assay data:2 Active, 2 Tested
Inhibition of recombinant MCH2 (unknown origin) assessed as ratio of irreversible rate constant K3 to dissociation constant of the reversible binding step Ki pre-incubated for 60 mins with Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate followed by enzyme addition by fluorescence based assay
Assay data:77 Tested
Inhibition of recombinant MCH2 (unknown origin) pre-incubated for 60 mins with Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate followed by enzyme addition by fluorescence based assay
Assay data:77 Active, 75 Activity ≤ 1 µM, 77 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant MCH2 (unknown origin) pre-incubated for 30 mins before Acetyl-Asp-Glu-Val-Asp-amino-4-methylcoumarin substrate addition measured 1 hr after substrate addition by fluorescence based assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
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