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Items: 1 to 20 of 1450

1.

Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
2.

Inhibition of cyclooxygenase-1 (unknown origin) at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
3.

Inhibition of human recombinant COX1 by ELISA

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
4.

Inhibition of COX1 in human platelets using arachidonic acid as substrate assessed as residual activity at 100 uM preincubated for 15 mins before substrate addition measured after 10 mins

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
5.

Inhibition of COX1 in human platelets using arachidonic acid as substrate assessed as residual activity at 10 uM preincubated for 15 mins before substrate addition measured after 10 mins

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
6.

Inhibition of COX1 in human platelets using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
7.

Inhibition of COX1 (unknown origin) by solid phase ELISA method

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
8.

Binding affinity to COX-1 (unknown origin) at 0.35 mM after 30 mins by [13C] NMR spectroscopy

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
9.

Binding affinity to COX-1 (unknown origin) by ESI mass spectrometry

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
10.

Inhibition of COX1 (unknown origin)

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
11.

Inhibition of COX1 (unknown origin) using arachidonic acid as substrate at 0.25 uM after 10 mins by luminometry

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
12.

Inhibition of human recombinant COX2 pre-incubated for 15 mins before arachidonic acid addition by fluorescence micro plate reader method

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
13.

Inhibition of COX-1 in human OVCAR3 cells by cell-based assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
14.

Inhibition of human recombinant COX1 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assay

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
15.

Inhibition of COX1 in human U937 cells at 10 uM

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
16.

Inhibition of recombinant COX-1 (unknown origin) at 0.1 uM

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
17.

Inhibition of recombinant COX-1 (unknown origin) at 10 uM

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
18.

Inhibition of COX1-mediated PGD2 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
19.

Inhibition of COX1-mediated PGF2alpha formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
20.

Inhibition of COX1-mediated PGE2 production in human platelets assessed as formation of 12-HHT using arachidonic acid as substrate preincubated for 5 mins measured after 5 mins by RP-HPLC analysis

Source:
ChEMBL
Protein Target:
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
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