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TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:58 Active, 25 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of DHFR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DHFR (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of DHFR (unknown origin) at pH 6.7
Inhibition of recombinant human DHFR expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:6 Active, 1 Activity ≤ 1 µM, 34 Tested
Inhibition of recombinant human DHFR expressed in Escherichia coli incubated for 15 mins and measured by ELISA
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Kinase Inhibition Assay from US Patent US11111252: "Pyrimidine compounds and pyrimido indole compounds and methods of use"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibitory Activity Assay from US Patent US11078214: "Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US11001595: "Pyrimidine compounds and pyrimido indole compounds and methods of use"
Assay data:8 Active, 4 Activity ≤ 1 µM, 9 Tested
Enzyme Inhibition from US Patent US10870625: "Zwitterionic propargyl-linked antifolates useful for treating bacterial infections"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
Biological Assay from Article 10.3109/14756360903179443: "Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms."
Assay data:13 Active, 11 Activity ≤ 1 µM, 21 Tested
Dihydrofolate Reductase (DHFR) Inhibition Assay from Article 10.1016/j.bioorg.2017.04.019: "Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors"
Assay data:11 Active, 5 Activity ≤ 1 µM, 20 Tested
DHFR Inhibition Assay from Article 10.1111/cbdd.12681: "Synthesis, Antifolate and Anticancer Activities of N(5) -Substituted 8,10-Dideazatetrahydrofolate Analogues."
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
Enzyme Inhibition Assay from US Patent US8853228: "Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Spectrophotometric Enzyme Assay from US Patent US8853228: "Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition Assay from US Patent US8835445: "Dihydrofolate reductase inhibitors"
Assay data:40 Active, 31 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
Inhibition Assay from Article 10.1111/j.1747-0285.2009.00860.x: "Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates."
Assay data:13 Active, 12 Activity ≤ 1 µM, 15 Tested
Enzyme Inhibition Assay from Article 10.1111/j.1747-0285.2008.00745.x: "Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors."
Assay data:13 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
Enzyme Inhibition Assay from Article 10.1016/j.chembiol.2008.07.013: "Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase."
Assay data:12 Active, 10 Activity ≤ 1 µM, 12 Tested
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