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Inhibition of Trypanosoma brucei phosphofructokinase
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay
Assay data:29 Active, 14 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate at 57 uM by luciferase based luminescence assay
Assay data:37 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Trypanosoma cruzi PFK
Assay data:26 Active, 14 Activity ≤ 1 µM, 42 Tested
Inhibition of Trypanosoma cruzi PFK at 57 uM
Competitive inhibition Trypanosoma brucei PFK using fructose-6-phosphate as substrate by Line-weaver Burk plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Mixed type inhibition Trypanosoma brucei PFK using ATP as substrate by Line-weaver Burk plot analysis
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: T. brucei in vitro Parasite Assay
Assay data:5 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: High F6P
Assay data:18 Active, 40 Tested
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: High ATP
Assay data:29 Active, 6 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: ATP-depletion Assay
Assay data:29 Active, 10 Activity ≤ 1 µM, 40 Tested
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: Counter Screen against T cruzi PFK
Assay data:30 Active, 10 Activity ≤ 1 µM, 40 Tested
Confirmatory Assay to Find Inhibitors of T. brucei phosphofructokinase: probe SAR
Inhibitors of T. brucei phosphofructokinase: Hit Validation
Assay data:432 Active, 26 Activity ≤ 1 µM, 1054 Tested
Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation
Assay data:491 Active, 43 Activity ≤ 1 µM, 1054 Tested
qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation
Assay data:18 Active, 5 Activity ≤ 1 µM, 2475 Tested
qHTS Assay to Find Inhibitors of T. brucei Phosphofructokinase: Summary
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase
Assay data:37 Active, 202 Activity ≤ 1 µM, 1280 Tested
qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase
Assay data:560 Active, 363 Activity ≤ 1 µM, 331108 Tested
Ratio of Ki/Km for Trypanosoma brucei PFK expressed in Escherichia coli using fructose-6-phosphate by spectrophotometry analysis
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