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Inhibition of rat glutathione reductase by spectrophotometric method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Recombinant TrxR1 and GR from US Patent US11208384: "Sulfinylpyridines and their use in the treatment of cancer"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US11168069: "Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of Recombinant TrxR1 from US Patent US11161815: "Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested
Inhibition Assay from US Patent US11028067: "Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Glutathione Reductase Activity Assay from Article 10.3109/14756366.2012.688042: "Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Activity Assay from Article 10.3109/14756366.2011.572879: "In vitro effects of some drugs on human erythrocyte glutathione reductase."
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human GR oxidoreductase activity by DTNB-reagent based spectrophotometric method
Assay data:6 Tested
Inhibition of GR in human HT-29 cells incubated for 24 hrs in presence of GSSG and NADPH
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inverse agonist activity at GHSR in Wistar rat pancreatic islets assessed as inhibition of ghrelin-induced insulinostatic action after 1 hr in presence of glucose
Assay data:1 Active, 1 Tested
Inhibition of NADPH-reduced rat glutathione reductase at 1 to 5 uM incubated for 1 hr in presence of NADPH and GSSG
Activation of recombinant human glutathione reductase using GSSG as substrate preincubated for 5 mins followed by substrate and NADPH addition
Effect on glutathione reductase catalytic activity in human HL60 cells
Assay data:2 Tested
Human glutathione-disulfide reductase (1.-.-.- Oxidoreductases)
SummaryCompounds, ActiveRelated BioAssays by Target
Effect on glutathione reductase activity in human MCF7 cells using GSSG as substrate at 1.25 to 20 uM after 24 hrs by spectrophotometric analysis
In vitro inhibition of NADPH-reduced GR (unknown origin) up to 40 uM after 2 hrs incubation
Inhibition of rat recombinant glutathione reductase after 30 mins by DTNB assay
Inhibition of Mus musculus (mouse) glutathione reductase isolated from liver at 200 uM
Assay data:107 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assay
Assay data:1 Active, 19 Tested
Inhibition of glutathione reductase up to 200 uM
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