Format
Items per page
Sort by

Send to:

Choose Destination

Links from

Items: 1 to 20 of 248

1.

Induction of human PXR

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
2.

Antagonist activity at PXR (unknown origin)

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
3.

Antagonist activity against PXR in human HepG2 cells assessed as inhibition of rifaximin-induced CYP3A4 gene expression at 25 uM after 18 hrs by quantitative real-time PCR analysis

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
4.

Activity at PXR in human HepG2 cells assessed as up regulation of rifaximin-induced CYP3A4 gene expression at 25 uM after 18 hrs by quantitative real-time PCR analysis

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
5.

Transactivation of PXR in human HepG2 cells assessed as up regulation of CYP3A4 gene expression at 10 uM after 18 hrs by quantitative Real-time PCR analysis

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
6.

Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation after 18 hrs by luciferase reporter assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
7.

Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximin

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
8.

Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation at 50 uM after 18 hrs by luciferase reporter assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
9.

Transactivation of full length human PXR (unknown origin) transfected in human HepG2 cells at 10 uM after 18 hrs by luciferase reporter assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
10.

Activation of human PXR relative to control

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
11.

Activation of human PXR

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
12.

Transactivation of human PXR

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
13.

Activation of PXR (unknown origin)

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
14.

Activation of PXR (unknown origin)

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
15.

Agonist activity at GAL4-fused human PXR expressed in HEK293 cells assessed as activation of basal transcriptional activity up to 10 uM after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
16.

Antagonist activity at GAL4-fused human PXR expressed in HEK293 cells assessed as inhibition of T0901317-stimulated transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
17.

Activation of PXR (unknown origin)

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
18.

Activation of PXR (unknown origin) by receptor transactivation assay

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
19.

Activation of human PXR expressed in human HepG2 cells co-expressing CYP3A4 assessed as CYP3A4 activation at 10 uM by luciferase reporter gene assay relative to rifampicin

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
20.

Activation of PXR (unknown origin) at 10 uM relative to rifampicin

Source:
ChEMBL
Protein Target:
Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Refine your results

• What's this?

Actions on your results

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center