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Items: 1 to 20 of 54

1.

Inhibition of ASK1 (unknown origin) at 10 uM after 120 mins P33 radiolabeled kinase activity assay

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
2.

Mitogen-activated protein kinase kinase kinase 5 inhibitor

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
3.

Delta TM value showing the stabilisation of ASK1 produced by compound binding

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
4.

Inhibition of recombinant ASK1 catalytic subunit (unknown origin) assessed as residual enzyme activity at 10 uM using MBP substrate and gamma-labeled 32P ATP incubated for 20 mins by liquid scintillation counting method

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
5.

Inhibition of recombinant ASK1 catalytic subunit (unknown origin) using MBP substrate and gamma-labeled 32P ATP incubated for 20 mins by liquid scintillation counting method

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
6.

Inhibition of ASK1 (unknown origin) assessed as residual activity at 33 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
7.

Inhibition of human MAP3K5 by Off-chip mobility shift assay

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
8.

Inhibition of ASK1 (unknown origin) assessed as remaining enzyme activity at 10 uM by radioactive [33P]-ATP filter binding assay

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
9.

Inhibition of ASK1 (unknown origin) assessed as residual enzyme activity at 10 uM

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
10.

Inhibition of ASK1 (unknown origin)

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
11.

Mitogen-activated protein kinase kinase kinase 5 inhibitor

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
12.

AlphaScreen-based biochemical high throughput dose response assay to identify inhibitors of apoptosis signal-regulating kinase 1 (ASK1).

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
mitogen-activated protein kinase kinase kinase 5 [Homo sapiens]
13.
14.

AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of apoptosis signal-regulating kinase 1 (ASK1).

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
mitogen-activated protein kinase kinase kinase 5 [Homo sapiens]
15.

Inhibition of human MAP3K5 assessed as enzyme activity at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
16.

Inhibition of ASK1 (unknown origin) at 10 uM assessed as residual enzyme activity

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
17.

Inhibition of human ASK1 assessed as residual activity at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
18.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:
Shanghai Institute of Organic Chemistry
Protein Targets:
Chain 1, Crystal Structure Of Gamma-Chymotrypsin In Complex With 7- Hydroxycoumarin; ...
Total:
3277
AID:
977608
19.

Inhibition of ASK1 (unknown origin) at 10 uM

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
20.

Inhibition of ASK1 (unknown origin) assessed as residual activity at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
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