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Affinity Biochemical interaction (Radioligand binding assay for APP as target) EUB0000750a PSEN1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Abeta42 inhibition assay (electrochemiluminescent detection of peptides secreted by SH-SY5Y cells stably overexpressing the APP C-terminal fragment SPA4CT)) EUB0000753a PSEN1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Phenotypic Cellular interaction (Abeta40 inhibition assay (in SH-SY5Y (SP4CT) cells; APP as target)) EUB0000750a PSEN1
Affinity Phenotypic Cellular interaction (Abeta40 inhibition assay (in SH-SY5Y (SP4CT) cells; APP as target)) EUB0000741a PSEN1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Abeta42 inhibition assay (electrochemiluminescent detection of peptides secreted by SH-SY5Y cells stably overexpressing the APP C-terminal fragment SPA4CT)) EUB0000739a PSEN1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-42 level at 100 uM for 12 hrs by ELISA
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-40 level at 100 uM for 12 hrs by ELISA
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of NICD cleavage
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma secretase derived from human Hela cell membrane assessed as reduction in amyloid beta (1 to 40) production by ELISA
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 42 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-based assay
Inhibition of gamma-secretase in human H4 cells assessed as reduction in amyloid beta 42
Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levels
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta42 levels incubated for 2 hrs by sandwich ELISA
Assay data:4 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta40 levels incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta38 levels incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta37 levels incubated for 2 hrs by sandwich ELISA
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