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Items: 1 to 20 of 42

1.

Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells assessed as increase in current amplitude relative to control

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
2.

Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
3.

Inhibition of potassium channel IKs (unknown origin)

Source:
ChEMBL
Protein Target:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
4.

Voltage-gated potassium channel blocker

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily A member 10; Voltage-gated potassium channel subunit Kv1.8; ...
Total:
40
5.

KCNQ (Kv7) potassium channel blocker

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1; ...
Total:
5
6.

Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
7.

Inhibition of voltage-gated K channel 7.1 (unknown origin)

Source:
ChEMBL
Protein Target:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
8.

Inhibition of human KCNQ1/MINK at 10 uM

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
9.

Inhibition of human IKs at 33 uM

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
10.

Inhibition of human IKs expressed in CHO cells at 31.6 uM by patch clamp assay

Source:
ChEMBL
Protein Targets:
Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel; ...
Total:
2
11.

Inhibition of Kv7.1 channel expressed in CHO cells assessed as inhibition of depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control

Source:
ChEMBL
Protein Target:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
12.

Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control

Source:
ChEMBL
Protein Target:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
13.

Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay

Source:
ChEMBL
Protein Target:
Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
14.

Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels

Source:
Johns Hopkins Ion Channel Center
Protein Targets:
potassium voltage-gated channel subfamily E member 1 [Homo sapiens]; ...
Total:
2
15.

Validation for compounds that inhibit KCNQ1 potassium channels on automated electrophysiology assay

Source:
Johns Hopkins Ion Channel Center
Protein Target:
potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens]
16.

SAR analysis for compounds that activate KCNQ1 potassium channels in the KCNQ1 expressing cells on automated patch clamp III

Source:
Johns Hopkins Ion Channel Center
Protein Target:
potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens]
17.

SAR analysis for compounds that activate KCNQ1 potassium channels in the KCNQ1 expressing cells on automated patch clamp 2

Source:
Johns Hopkins Ion Channel Center
Protein Target:
potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens]
18.

Manual patch clamp assay to confirm a potent KCNQ1 activator

Source:
Johns Hopkins Ion Channel Center
Protein Target:
potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens]
19.

SAR analysis for compounds that activate KCNQ1 potassium channels in the KCNQ1 expressing cells on automated patch clamp

Source:
Johns Hopkins Ion Channel Center
Protein Target:
potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens]
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