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Items: 20

1.

Antagonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
2.

Agonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
3.

Inhibition of NOD2 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
4.

Modulation of NOD2 (unknown origin)

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
5.

Antagonist activity at NOD2 (unknown origin)

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
6.

Agonist activity at human Nod2 expressed in HEK293-blue cells assessed as increase in NF-kappaB transcriptional activity at 20 uM incubated for 18 hrs using quanti blue assay based SEAP reporter gene assay

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
7.

Inhibition of NOD-2 in human MCF7 cells assessed as inhibition of MDP-induced IL8 secretion at 0.25 to 5 uM by ELISA

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
8.

Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay

Source:
ChEMBL
Protein Target:
Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
15.

SAR analysis of compounds that inhibit NOD2 - Set 3

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
16.

SAR analysis of compounds that inhibit NOD2 - Set 2

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
17.

SAR analysis of compounds that inhibit NOD2 revised

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
18.

uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
19.

Summary assay for the identification of compounds that inhibit NOD2

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
20.

uHTS luminescence assay for the identification of compounds that inhibit NOD2

Source:
Burnham Center for Chemical Genomics
Protein Target:
nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens]
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