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Positive allosteric modulator activity at rat mGlu2 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2.5 mins followed by gluatamate addition by thallium flux assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Positive allosteric modulator activity at rat mGlu3 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2.5 mins followed by gluatamate addition by thallium flux assay
Agonist activity at mGluR3 (unknown origin) at 1 to 10 uM by Galphaqi5 calcium flux assay
Agonist activity at mGluR2 (unknown origin) at 1 to 10 uM by cAMP assay
Positive allosteric modulation of mGluR3 (unknown origin)
Positive allosteric modulation of mGluR2 (unknown origin)
Positive allosteric modulation of human mGluR3
Positive allosteric modulation of human mGluR2
Antagonist activity at human mGlur2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assessment of mGlu2 Receptor Negative Allosteric Modulator Activity from US Patent US11633395: "Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor"
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Positive allosteric modulator activity at mGluR2 receptor (unknown origin) assessed as glutamate-induced [35S]GTPgammaS binding
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mGlu3 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay
Assay data:1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
Positive allosteric modulation of mGlu2 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells in presence of L-glutamate by luciferase based GloSensor cAMP Assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested
Positive allosteric modulation of mGlu2 receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Negative allosteric modulator activity at human recombinant mGlur2 expressed in HEK293 cells by calcium assay
Negative allosteric modulation activity at human recombinant mGlur2 at 30 nM by cAMP Glosensor assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Negative allosteric modulation activity at human recombinant mGlur2 at 3 nM by cAMP Glosensor assay
Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay
Antagonist activity at human recombinant mGlur2 expressed in HEK293T cells assessed as protein induced changes in intracellular cAMP at 100 uM by Glosensor assay
Assay data:2 Active, 2 Tested
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