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Agonist activity at mGlu8 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay
Assay data:1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mGlu6 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay
Agonist activity at mGlu4 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP Assay
Agonist activity at human mGlu4 receptor assessed as increase in calcium flux
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human mGlu4 receptor assessed as increase in calcium flux by Fluo-4 AM dye based analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay relative to control
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay
Assay data:15 Active, 4 Activity ≤ 1 µM, 16 Tested
Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay relative to control
Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay
Assay data:20 Active, 10 Activity ≤ 1 µM, 23 Tested
In Vitro Pharmacology from US Patent US11414395: "Heterocyclic compounds as modulators of mGluR7"
Assay data:120 Active, 120 Activity ≤ 1 µM, 136 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Metabotropic Glutamate Receptor Activity from US Patent US11319304: "Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:121 Active, 121 Activity ≤ 1 µM, 121 Tested
Determination of EC50 values using a Ca2+ mobilization in vitro assay on recombinant human mGlu4 expressed in HEK293 cells from US Patent US11242349: "Ethynyl derivatives"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Metabotropic Glutamate Receptor Activity from US Patent US11242342: "Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:56 Active, 40 Activity ≤ 1 µM, 56 Tested
New CNS Specificity Data for AK3-238 (FA44) and AK3-99B (FA26) from US Patent US11173137: "Compositions and methods to modulate chloride ion channel activity"
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Biological Assay from US Patent US11034699: "Ethynyl derivatives"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Receptor Activity Assay from US Patent US10968227: "Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:45 Active, 45 Activity ≤ 1 µM, 45 Tested
Metabotropic Glutamate Receptor Activity from US Patent US10508105: "Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:117 Active, 117 Activity ≤ 1 µM, 117 Tested
Pharmacological Assay from US Patent US9212196: "Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof"
Assay data:31 Active, 20 Activity ≤ 1 µM, 33 Tested
Receptor Activity Assay from US Patent US9192603: "Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:61 Active, 32 Activity ≤ 1 µM, 66 Tested
Glutamate Receptor Activity from US Patent US9180192: "mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction"
Assay data:46 Active, 27 Activity ≤ 1 µM, 46 Tested
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