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Qube Assay from US Patent US11802122: "2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors"
Assay data:104 Active, 4 Activity ≤ 1 nM, 99 Activity ≤ 1 µM, 105 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Qube Assay from US Patent US20230312528: "2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS"
Assay data:172 Active, 5 Activity ≤ 1 nM, 156 Activity ≤ 1 µM, 176 Tested
Assays for Detecting and Measuring of NaV Inhibition from US Patent US11673864: "Pyridone amides as modulators of sodium channels"
Assay data:149 Active, 1 Activity ≤ 1 nM, 112 Activity ≤ 1 µM, 159 Tested
Electrophysiological Assay (In Vitro Assay) from US Patent US11639351: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Sodium Influx Assay (In Vitro Assay) from US Patent US11639351: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"
Assay data:47 Active, 28 Activity ≤ 1 µM, 48 Tested
Selectivity interaction (CEREP panel (GPCRs, ion channels, transporters, kinases)) EUB0000103c SCN2A
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (CEREP Wide Ligand screening panel (ion channels, receptors, enzymes)) EUB0000304b SCN2A
Selectivity interaction (CEREP panel (receptors, ion chanels, radiometric assay)) EUB0000192d SCN2A
Inhibition of human Nav1.5
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human Nav1.5 at 10 uM relative to control by Electrophysiological QPatch assay
Inhibition of human Nav1.5 expressed in CHO cells by manual patch clamp method
Inhibition of Nav1.5 (unknown origin)
Inhibition of human NaV1.5 at 10 uM relative to control
Inhibition of human Nav 1.8 by manual electrophysiology method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human Nav1.2 expressed in HEK293 cells incubated for 3 mins by FRET based membrane potential assay
Assay data:2 Active, 4 Tested
Inhibition of human Nav1.8 by FRET based membrane potential assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Nav 1.5 expressed in HEK293 cells at -90 mV holding potential by Whole cell voltage clamp electrophysiology assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 20 Tested
Inhibition of NaV1.5 (unknown origin)
Inhibition of Nav1.5 (unknown origin) at 10 uM
Inhibition of human Nav1.8 channel stably expressed in HEK293 cells assessed as sodium current flow at holding potential of -90mV by whole-cell voltage clamp assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
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