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No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GSK3β Kinase Assay from US Patent US20230286945: "ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF"
Assay data:188 Active, 1 Activity ≤ 1 nM, 64 Activity ≤ 1 µM, 238 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
GSK3beta Mobility Shift Assay from US Patent US11718603: "CDK2 inhibitors"
Assay data:328 Active, 2 Activity ≤ 1 nM, 349 Activity ≤ 1 µM, 349 Tested
GSK3β Kinase Activity Assay from US Patent US11713320: "5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof"
Assay data:137 Active, 1 Activity ≤ 1 nM, 124 Activity ≤ 1 µM, 143 Tested
Kinase assay from US Patent US10774086: "GSK-3 inhibitors"
Assay data:44 Active, 28 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
GSK3B Kinase Assay from US Patent US11673881: "Isoquinolin-3-yl carboxamides and preparation and use thereof"
Assay data:301 Active, 1 Activity ≤ 1 nM, 282 Activity ≤ 1 µM, 303 Tested
Inhibition of human wildtype full length GSK3 beta expressed in bacterial system at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000154b GSK3B
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b GSK3B
SummaryRelated BioAssays by Target
Selectivity interaction (Enzymatic assay) EUB0000624a GSK3B
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b GSK3B
Thermal Shift Assay. Domain: start/stop: M26-R383
Assay data:27 Tested
Inhibition of GSK3 (unknown origin) at 10 uM relative to control
Inhibition of human recombinant GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate measured after 30 mins by ADP-Glo kinase assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant GSK3beta expressed in baculovirus in Sf9 insect cells assessed as residual activity at 1 uM using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate measured after 30 mins in presence of ATP by ADP-Glo kinase assay relative to control
Assay data:20 Tested
Inhibition of GSK3beta (unknown origin)
Inhibition of GSK3b (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:3 Tested
Inhibition of human GSK3beta (2 to end residues) assessed as residual activity using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate at 1 uM incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
Inhibition of GSK3-beta in human HEK293T cells harboring tau P301L mutant assessed as increase in GSK3-beta phosphorylation at Ser9 residue measured after 48 hrs by western blot analysis
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