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Protein Kinase C beta 2 (PKCpII) Assay from US Patent US11780853: "Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors"
Assay data:93 Active, 5 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of [3H]-PDBu binding to PKCalpha C1A domain (unknown origin) by competitive binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a PRKCA
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (ProQinase, FlashPlate?-based radiometric assay, 10 M ATP)) EUB0000006b PRKCB
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b PRKCA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000704a PRKCA
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCG
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCB
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCA
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCG
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCB
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCA
Inhibition of PKCalpha (unknown origin) at 1 uM in presence of ATP at Km concentration by mobility shift assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PRKCA (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
Inhibition of PKCb2 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PKCbeta2 (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCbeta1 (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCalpha (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKbeta (unknown origin)
Inhibition of PKCbeta2 (unknown origin) by IMAP kinase assay
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