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SPR Assay from US Patent US11786528: "Pyrazolopyrimidine compounds as adenosine receptor antagonists"
Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Adenosine Receptor Time-Resolved Fluorescence Resonance Energy Transfer (TRFRET) Binding Assay from US Patent US20230293517: "ANTAGONIST COMPOUNDS"
Assay data:258 Active, 137 Activity ≤ 1 nM, 258 Activity ≤ 1 µM, 258 Tested
Adenosine Receptor Binding Assay from US Patent US20230271964: "5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER"
Assay data:98 Active, 42 Activity ≤ 1 nM, 98 Activity ≤ 1 µM, 98 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding Affinities to Different Adenosine Receptors from US Patent US11629147: "Triazolo-pyrimidine compounds and uses thereof"
Assay data:21 Active, 5 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Binding Affinities to Different Adenosine Receptors from US Patent US11571420: "Pyrazine compounds and uses thereof"
Assay data:37 Active, 2 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 38 Tested
Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b ADORA1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (CEREB panel (GPCRs, ion channels, and transporters)) EUB0000323b ADORA1
Selectivity interaction (Eurofins CEREP Diversity Profiling (71 receptors, ion channels, and 25 other enzymes)) EUB0000231c ADORA1
Selectivity interaction (CEREP panel (receptors, ion channels, and transporters)) EUB0000205c ADORA1
Selectivity interaction (CEREP panel (LeadProfilingScreen Eurofins, panel of receptors, ion channels, and other enzymes)) EUB0000191c ADORA1
Displacement of [3H]DPCPX from human A1AR incubated for 60 mins by scintillation counter analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human adenosine A1 receptor
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H] N6-R-phenylisopropyladenosine from mouse A1A receptor stably expressed in HEK293 cell membrane by radioligand inhibition assay
Assay data:12 Active, 8 Activity ≤ 1 µM, 12 Tested
Displacement of [3H] N6-R-phenylisopropyladenosine from human A1A receptor stably expressed in HEK293 cell membrane by radioligand inhibition assay
Binding affinity to mouse adenosine A1A receptor expressed in human HEK293 cell membrane by radioligand inhibition assay
Assay data:9 Tested
Binding affinity to human adenosine A1A receptor expressed in human HEK293 cell membrane at 10 uM by radioligand inhibition assay
Assay data:28 Tested
Displacement of [3H]DPCPX from human A1AR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method
Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested
Binding affinity to human wild type A1R expressed in CHO-K1 by schild plot analysis
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