Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of human caspase 3 using Ac-Asp-Glu-Val-Asp-pNA as substrate by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of caspase-3/7 activity in human 518A2 cells at 25 nM preincubated for 24 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of caspase-3/7 activity in human 518A2 cells at 1 uM preincubated for 6 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:1 Active, 1 Tested
Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assay
Assay data:2 Tested
Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysis
Assay data:32 Active, 27 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of caspase-3 (unknown origin)
Inhibition of Caspase Activity Assay from US Patent US11447497: "(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Inhibition of UAWJ9-36-1 and UAWJ9-36-3 against the Mpro's from Seven Human Coronaviruses from Article 10.1021/acsptsci.1c00099: "Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9345789: "Specific inhibitors and active site probes for legumain"
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:17 Active, 17 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Procaspase-3 Activation Assay from Article 10.1038/nchembio814: "Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy."
Assay data:2 Active, 2 Activity ≤ 1 µM, 10 Tested
Enzyme kinetic assay from Article 10.1021/cb900232a: "Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Caspase-3 Inhibition Assay from Article 10.1016/j.bmc.2009.09.036: "3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3."
Assay data:33 Active, 29 Activity ≤ 1 µM, 33 Tested
Enzyme Inhibition Assay from Article 10.1021/jm900135r: "Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6."
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2003.10.064: "Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Caspase Inhibition Assay from Article 10.1021/jm0305523: "Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis."
Assay data:8 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 8 Tested
Caspase Inhibition Assay from Article 10.1016/s0960-894x(03)00390-1: "Nicotinyl aspartyl ketones as inhibitors of caspase-3."
Assay data:18 Active, 14 Activity ≤ 1 µM, 26 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2005.05.116: "Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors."
Assay data:29 Active, 26 Activity ≤ 1 µM, 29 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on