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Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions via Bim (BCL2-like 11)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis of selective Bcl-B inhibitors using fluorescence polarization assay, set 2
Assay data:4 Active, 2 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Isothermal titration calorimetry (ITC) with Bcl-B and compounds active in primary screen
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis of selective Bcl-B inhibitors using a Fluorescence Polarization Bcl-XL/Bim-BH3 Assay
Assay data:58 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis of selective Bcl-B inhibitors using fluorescence polarization assay
Assay data:16 Active, 3 Activity ≤ 1 µM, 58 Tested
Bcl-2 family members Fluorescence polarization assay with Set1 of powder compounds
Assay data:4 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Dose response of powder sourced compounds for small molecule regulators of Bcl-2 family protein interactions, panel upload with wildtype and mutant Bfl1 and wildtype BclB.
Assay data:3 Active, 22 Tested
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1
Assay data:1 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL
Assay data:42 Tested
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W
Assay data:5 Active, 1 Activity ≤ 1 µM, 42 Tested
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1
Assay data:23 Active, 5 Activity ≤ 1 µM, 42 Tested
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B
Assay data:9 Active, 4 Activity ≤ 1 µM, 42 Tested
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
Assay data:6 Active, 1 Activity ≤ 1 µM, 42 Tested
Profiling compound fluorescence on GSH Beads with 488 nm excitation and 530 nm emission
Assay data:489 Active, 194920 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
Assay data:18 Active, 8 Activity ≤ 1 µM, 834 Tested
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1.
Assay data:3 Active, 3 Activity ≤ 1 µM, 834 Tested
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
Assay data:9 Active, 6 Activity ≤ 1 µM, 834 Tested
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein.
Assay data:6 Active, 3 Activity ≤ 1 µM, 834 Tested
Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays (HPSMTB buffer)
Assay data:19 Active, 3 Activity ≤ 1 µM, 834 Tested
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
Assay data:6 Active, 5 Activity ≤ 1 µM, 834 Tested
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