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Binding affinity to 80S ribosome in human HuH7 cells expressing human C-terminal V5/6-His-tagged PCSK9 assessed as inhibition of PCSK9 secretion after 16 to 24 hrs by AlphaLISA method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human 80S ribosome-mediated PCSK9 translation expressed in CHO-K1 cells assessed as reduction in PCSK9 secretion
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to 80S ribosome in human HuH7 cells harboring human PCSK9 (1 to 152 residues)-proLuc assessed as inhibition of PCSK9 mRNA translation at 20 uM after overnight incubation by luciferase reporter gene assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to 80S ribosome in human HeLa cells lysates using human full length PCSK9 encoding mRNAs assessed as inhibition of PCSK9 mRNA translation after 45 mins by Steady-Glo luciferase reporter gene assay
Assay data:10 Active, 3 Activity ≤ 1 µM, 10 Tested
Binding affinity to 80S ribosome in human HuH7 cells harboring human PCSK9 (1 to 152 residues)-proLuc assessed as inhibition of PCSK9 mRNA translation after overnight incubation by luciferase reporter gene assay
Assay data:7 Active, 2 Activity ≤ 1 µM, 9 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Displacement of [3H]PF-06446846 from human 80S ribosome
Assay data:1 Active, 2 Tested
Binding affinity to 80S ribosome in human HuH7 cells assessed as inhibition of PCSK9 mRNA translation at 20 uM after overnight incubation by ELISA relative to control
Assay data:2 Tested
Binding affinity to 80S ribosome in human HuH7 cells assessed as inhibition of PCSK9 mRNA translation after overnight incubation by ELISA
Assay data:14 Active, 4 Activity ≤ 1 µM, 14 Tested
Binding affinity to 80S ribosome in human HuH7 cells harboring pCMV-truncated human PCSK9 (1 to 152 residues)-proLuc assessed as inhibition of PCSK9 mRNA translation at 20 uM after overnight incubation by luciferase reporter gene assay relative to control
Binding affinity to 80S ribosome in human HuH7 cells harboring pCMV-truncated human PCSK9 (1 to 152 residues)-proLuc assessed as inhibition of PCSK9 mRNA translation after overnight incubation by luciferase reporter gene assay
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Binding affinity to RPS2 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPS9 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPL9 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPL19 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPL10A in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPL5 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPS11 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPL31 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to RPS17 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
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