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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000310b EIF2AK2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000316c EIF2AK2
Binding affinity to wild type EIF2AK2 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKR (unknown origin) assessed as fold change
Inhibition of PKR (unknown origin)
PRKR DiscoveRx kinase panel
PKR(h) Kinase panel
Inhibition of EIF2AK2 (unknown origin) assessed as residual activity at 5 uM
Inhibition of EIF2AK2 (unknown origin) at 1000 nM relative to control
PKR KinaseGlo Assay from US Patent US10669265: "Pyridyl benzothiophenes as kinase inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
KinaseGlo Assay from US Patent US10633373: "Pyridyl benzothiophenes as kinase inhibitors"
KinaseGlo Assay from US Patent US10011593: "Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors"
Assay data:10 Active, 10 Activity ≤ 1 µM, 12 Tested
PKR KinaseGlo Assay from US Patent US9868726: "Pyridyl benzothiophenes as kinase inhibitors"
PDGFRβ Kinase Assay from US Patent US9650366: "Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors"
KinomeScan assay: inhibition of PRKR
Assay data:108 Tested
PKR(EIK2LGY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
PKR(h) Eurofins kinase panel
EIF2AK2 ProQinase selectivity panel
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