BioAssay by Target (List) for Gene (Select 5610) - PubChem BioAssay - NCBI

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Select item 19151901.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000310b EIF2AK2

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1915190

Summary Related BioAssays by Target

Select item 19145022.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000316c EIF2AK2

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1914502

Summary Related BioAssays by Target

Select item 18667013.

Binding affinity to wild type EIF2AK2 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1866701

Summary PubMed Citation Related BioAssays by Target

Select item 18567214.

Inhibition of PKR (unknown origin) assessed as fold change

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1856721

Summary PubMed Citation Related BioAssays by Target

Select item 18567125.

Inhibition of PKR (unknown origin)

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1856712

Summary PubMed Citation Related BioAssays by Target

Select item 18355596.

PRKR DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1835559

Summary Related BioAssays by Target

Select item 18351237.

PKR(h) Kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1835123

Summary Related BioAssays by Target

Select item 18200858.

Inhibition of EIF2AK2 (unknown origin) assessed as residual activity at 5 uM

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1820085

Summary PubMed Citation Related BioAssays by Target

Select item 18107369.

Inhibition of EIF2AK2 (unknown origin) at 1000 nM relative to control

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1810736

Summary PubMed Citation Related BioAssays by Target

Select item 180447910.

PKR KinaseGlo Assay from US Patent US10669265: "Pyridyl benzothiophenes as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Interferon-induced, double-stranded RNA-activated protein kinase; ...
Total:: 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1804479

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180437111.

KinaseGlo Assay from US Patent US10633373: "Pyridyl benzothiophenes as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Interferon-induced, double-stranded RNA-activated protein kinase; ...
Total:: 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1804371

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179932612.

KinaseGlo Assay from US Patent US10011593: "Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Interferon-induced, double-stranded RNA-activated protein kinase; ...
Total:: 1

Assay data:10 Active, 10 Activity ≤ 1 µM, 12 Tested

AID:: 1799326

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179798613.

PKR KinaseGlo Assay from US Patent US9868726: "Pyridyl benzothiophenes as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Interferon-induced, double-stranded RNA-activated protein kinase; ...
Total:: 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1797986

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179622714.

PDGFRβ Kinase Assay from US Patent US9650366: "Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Interferon-induced, double-stranded RNA-activated protein kinase; ...
Total:: 1

Assay data:10 Active, 10 Activity ≤ 1 µM, 12 Tested

AID:: 1796227

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179430115.

KinomeScan assay: inhibition of PRKR

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:108 Tested

AID:: 1794301

Summary Related BioAssays by Target

Select item 179365616.

PKR(EIK2LGY1) Takeda global kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1793656

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179336517.

PKR(EIK2LGY1) Takeda global kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1793365

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179307118.

PKR(EIK2LGY1) Takeda global kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1793071

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179282019.

PKR(h) Eurofins kinase panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1792820

Summary Related BioAssays by Target

Select item 179227020.

EIF2AK2 ProQinase selectivity panel

Source:: ChEMBL

Protein Target:: Interferon-induced, double-stranded RNA-activated protein kinase

Assay data:1 Tested

AID:: 1792270

Summary Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (18)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (18)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (24)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (98)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (76)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (63)
BioAssays deposited by other experimentalists

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