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Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constant
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to CM5 sensor chip immobilized human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured after 6 mins by SPR analysis
Assay data:1 Active, 2 Tested
Inhibition of human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaScreen assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PARP14 MD2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PARP14 (unknown origin) by TR-FRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of PARP14 (unknown origin)
Assay data:9 Active, 5 Activity ≤ 1 µM, 10 Tested
Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of PARP14 (unknown origin) incubated for 1 hr by ELISA
Assay data:2 Active, 4 Tested
Inhibition of N-terminal his-tagged human PARP14 expressed in Escherichia coli Rosette2 (DE3)
Inhibition of PARP14 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)
Assay data:1 Tested
Inhibition of PARP14 (unknown origin) expressed in bacterial expression system using histone substrate incubated for 60 mins by chemiluminescence assay
Inhibition of PARP-14 (unknown origin)
Assay data:1 Active, 1 Tested
Displacement of a biotinylated small molecule probe from human PARP14 catalytic domain incubated for 30 mins by TR-FRET assay
Inhibition of human PARP14 using NAD+ as substrate incubated for 10 mins by fluorescence based analysis
Assay data:1 Active, 22 Tested
Inhibition of N-terminal His-tagged human PARP14 wwe-catalytic domain expressed in Escherichia coli BL21 (DE3) at 10 uM preincubated with 6-a-NAD+ for 5 to 10 mins followed by enzyme addition and measured after 60 mins using NAD+ as substrate byHRP based chemiluminescence assay
Assay data:6 Tested
Inhibition of PARP14 (unknown origin) using NAD+ as substrate incubated for 18 hrs by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 8 Tested
Enzymatic Assay from US Patent US11008308: "Quinazolinones as PARP14 inhibitors"
Assay data:385 Active, 285 Activity ≤ 1 µM, 420 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Inhibition Assay from US Patent US10562891: "Quinazolinones as PARP14 inhibitors"
Assay data:392 Active, 287 Activity ≤ 1 µM, 427 Tested
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