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No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Pim-1 Inhibitory Activity Assay from US Patent US11643417: "Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof"
Assay data:144 Active, 109 Activity ≤ 1 nM, 144 Activity ≤ 1 µM, 144 Tested
Kinase Biological Assay from US Patent US11597733: "Compounds and compositions for the treatment of parasitic diseases"
Assay data:4 Active, 19 Activity ≤ 1 µM, 19 Tested
Selectivity interaction (Kinase Profiler (Millipore)) EUB0000603a PIM1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (PSP kinase safety panel (Eurofins)) EUB0000283b PIM1
Selectivity interaction (Enzymatic assay) EUB0000624a PIM1
Selectivity interaction (Kinase panel (Millipore, radiometric filter-binding assay, conc. ATP = Km)) EUB0000613a PIM1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Cellular assay) EUB0000613a PIM1
Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c PIM1
Thermal Shift Assay. Domain: start/stop: M1-S312
Assay data:27 Tested
Inhibition of recombinant human PIM1 expressed in bacterial expression system assessed as residual activity at 1 uM using histone H1 as substrate measured after 30 mins in presence of ATP by ADP-Glo assay relative to control
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human PIM1 expressed in bacterial expression system using histone H1 as substrate measured after 30 mins in presence of ATP by ADP-Glo assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PIM1
Binding affinity to human PIM1
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human full length recombinant Pim1 assessed as residual activity at 1 uM using KKRNRTLTV as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
Inhibition of human PIM1 at 1 uM by DiscoverX KINOMEscan assay relative to control
Inhibition of PIM1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of His6-tagged full length human recombinant PIM1 expressed in Sf9 insect cells at 1 uM incubated for 60 mins in presence of [gamma33P]ATP by microplate scintillation counter relative to control
Inhibition of PIM1 (unknown origin) at 1.0 uM relative to control
Inhibition of PIM1 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control
Assay data:2 Tested
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