BioAssay by Target (List) for Gene (Select 3776) - PubChem BioAssay - NCBI

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Select item 19196151.

LMPTP Primary Screening Protocol from US Patent US10626094: "Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof"

Source:: BindingDB

Protein Targets:: Potassium channel subfamily K member 2; ...
Total:: 1

Assay data:260 Active, 52 Activity ≤ 1 µM, 332 Tested

AID:: 1919615

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18706292.

Activation of human TREK-1 channel expressed in CHO cells at 10 uM by patch clamp electrophysiology method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Active, 1 Tested

AID:: 1870629

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18706123.

Activation of human TREK-1 expressed in CHO cells at 10 uM in presence of ML335 by patch clamp electrophysiology method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:2 Active, 2 Tested

AID:: 1870612

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18494974.

Inhibition of human TREK-1 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1849497

Summary PubMed Citation Related BioAssays by Target

Select item 18021505.

TREK1 Assay from Article 10.1111/cbdd.12810: "Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently."

Source:: BindingDB

Protein Targets:: Potassium channel subfamily K member 2; ...
Total:: 1

Assay data:18 Active, 7 Activity ≤ 1 µM, 28 Tested

AID:: 1802150

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16758846.

Inhibition of human TREK1 at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:3 Active, 3 Tested

AID:: 1675884

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 16758837.

Effect on channel conductance of human TREK1 expressed in CHO cells by single-channel recordings based by inside-out patch method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1675883

Summary PubMed Citation Related BioAssays by Target

Select item 16758828.

Inhibition of human TREK1 at intermediate transition state expressed in CHO cells assessed as decrease in probability of TREK1 channel being in open state by single-channel recordings based by inside-out patch method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Active, 1 Tested

AID:: 1675882

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 16758819.

Inhibition of human TREK1 T211A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1675881

Summary PubMed Citation Related BioAssays by Target

Select item 167588010.

Inhibition of human TREK1 M291A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1675880

Summary PubMed Citation Related BioAssays by Target

Select item 167587911.

Inhibition of human TREK1 W295A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1675879

Summary PubMed Citation Related BioAssays by Target

Select item 167587812.

Inhibition of human TREK1 V288A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Active, 1 Tested

AID:: 1675878

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 167587713.

Inhibition of human TREK1 S290A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:2 Active, 3 Tested

AID:: 1675877

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 167587614.

Inhibition of human TREK1 D294A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Active, 3 Tested

AID:: 1675876

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 167587315.

Inhibition of human TREK1 R207A mutant at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Active, 2 Tested

AID:: 1675873

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 167587216.

Inhibition of human TREK1 in open state expressed in CHO cells in presence of 10 uM TREK1 activator arachidonic acid by whole-cell patch-clamp electrophysiological method

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:1 Tested

AID:: 1675872

Summary PubMed Citation Related BioAssays by Target

Select item 167291217.

Activation of human TREK1 at 30 uM by thallium flux mobilization assay relative to control

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:33 Tested

AID:: 1672912

Summary PubMed Citation Related BioAssays by Target

Select item 167291118.

Activation of human TREK1 at 10 uM by thallium flux mobilization assay relative to control

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:4 Tested

AID:: 1672911

Summary PubMed Citation Related BioAssays by Target

Select item 167290819.

Activation of human TREK1 by thallium flux mobilization assay

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:9 Active, 21 Tested

AID:: 1672908

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 162213720.

Antagonist activity at K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as suppression of channel currents at 20 uM at 0 mV holding potential by two-electrode voltage clamp assay relative to control

Source:: ChEMBL

Protein Target:: Potassium channel subfamily K member 2

Assay data:5 Tested

AID:: 1622137

Summary Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (48)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (4)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (34)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (153)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (75)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (90)
BioAssays deposited by other experimentalists

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