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NR2B Radioligand Binding Assay from US Patent US11752155: "Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders"
Assay data:11 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Whole-Cell Patch Clamp from US Patent US11613556: "Oxysterols and methods of use thereof"
Assay data:4 Active, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to TCP-stimulated NMDA (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to NMDA receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GluN1/N2A expressed in HEK293 cells assessed as NMDA/glycine-induced fraction of total transmembrane voltage field at 10 uM preincubated for 20 secs followed by NMDA treatment for 10 secs by patch-clamp method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GluN1/N2A (unknown origin) expressed in human tsA201 cells assessed as glutamate-induced change in voltage at -65 mV holding potential for 30 secs by whole-cell patch-clamp method
Binding affinity to NMDAR (unknown origin) assessed as inhibition constant by [3H]MK-801 binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Positive allosteric modulator activity at GluN1a/GluN2A (unknown origin) expressed in CHO cells assessed as maximum potentiation at 30 uM in presence of glutamate by Ca2+ influx assay relative to control
Assay data:16 Tested
Positive allosteric modulator activity at GluN1a/GluN2A (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assay
Assay data:10 Active, 5 Activity ≤ 1 µM, 13 Tested
Positive allosteric modulator activity at GluN2A receptor (unknown origin) assessed as maximum potentiation by FLIPR assay relative to control
Assay data:3 Tested
Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control
Assay data:17 Tested
Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method
Assay data:17 Active, 16 Activity ≤ 1 µM, 22 Tested
Inhibition of NMDA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control
Assay data:1 Tested
Antagonist activity at GluN1/GluN2A NMDA receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of glycine induced current response at 10 uM in presence of L-glutamate by patch-clamp method
Inhibition of NMDA receptor (unknown origin)
Binding affinity to NMDA receptor (unknown origin) at 100 uM patch clamp assay
Assay data:10 Tested
Antagonist activity at NMDA receptor (unknown origin) assessed as NMDA-induced depolarizations
Assay data:4 Tested
Displacement of [3H]MK-801 from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
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