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In Vitro SIK2 Kinase Assay from US Patent US20240025892: "SALT INDUCIBLE KINASE INHIBITORS"
Assay data:66 Active, 5 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 66 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor from US Patent US20230348453: "HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
Selectivity interaction (Kinase panel (activity or binding assay)) EUB0000674a SIK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of full length N-terminal nanoLuc-tagged human SIK1 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human SIK1 by radiometric PanQinase activity assay
Inhibition of human SIK1 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SIK1 (unknown origin)
Inhibition of GST fused recombinant SIK1 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1 hr in presence of ATP by autoradiography based immunoblotting analysis
Inhibition of human SIK by kinase assay
Inhibition of SIK (unknown origin) at 1 uM
Inhibition of GST fused recombinant SIK1 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1 hr in presence of ATP by autoradiography based immunoblotting analysis
SIK DiscoveRx kinase panel
SummaryRelated BioAssays by Target
SIK(h) Kinase panel
Cellular target engagement assay with: SIK1
Inhibition of SIK1 (unknown origin) at 1 uM
KinomeScan assay: inhibition of SIK
Assay data:108 Tested
SIK(SIK1LHY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
SIK(h) Eurofins kinase panel
SIK(h) Eurofins Kinase panel
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