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Inhibition of human CCR7 at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against CCR7 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CCR7 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CCR7)
SummaryRelated BioAssays by Target
Antagonist activity at CCR7 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM
Antagonist activity at human Gi/G0-coupled CCR7 receptor assessed as inhibition of CCL19-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL19 stimulation and measured after 90 to 180 mins by pathhunter assay
Inhibition of CCR7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at CCR7 (unknown origin) at 10 uM
Assay data:3 Tested
Antagonist activity at human CCR7 expressed in CHOK1 cells assessed as inhibition of CCL19-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins
Antagonist activity at CCR7 (unknown origin)
Agonist activity at CCR7 (unknown origin)
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human CCR7 (Chemokine receptors)
Assay data:3 Active, 3 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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