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LOX Inhibition Assay from US Patent US12178791: "Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof"
Assay data:53 Active, 47 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Ray2010 Assay 72 from Article : "Psychedelics and the human receptorome."
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Ray2010 Assay 70 from Article : "Psychedelics and the human receptorome."
Ray2010 Assay 55 from Article : "Psychedelics and the human receptorome."
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Ray2010 Assay 54 from Article : "Psychedelics and the human receptorome."
Ray2010 Assay 52 from Article : "Psychedelics and the human receptorome."
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Ray2010 Assay 49 from Article : "Psychedelics and the human receptorome."
SummaryPubMed CitationRelated BioAssays by Depositor
Ray2010 Assay 44 from Article : "Psychedelics and the human receptorome."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Ray2010 Assay 40 from Article : "Psychedelics and the human receptorome."
Ray2010 Assay 12 from Article : "Psychedelics and the human receptorome."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Carbonic Anhydrase (CA) II Inhibition Assay from Article 10.1016/j.bioorg.2015.08.001: "Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor."
Assay data:15 Tested
SummaryPubMed CitationRelated BioAssays by Target
Time-Dependent Inhibition Assay from Article 10.1074/jbc.m701335200: "Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides."
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
DNA Polymerase Activity Assay from Article 10.1128/aac.01311-05: "Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
GGTase-I Activity Assay from Article 10.1016/s0960-894x(03)00095-7: "Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives."
Assay data:2 Active, 2 Tested
FTase Activity Assay from Article 10.1016/s0960-894x(03)00095-7: "Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives."
Assay data:11 Active, 3 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."
Assay data:22 Active, 17 Activity ≤ 1 µM, 22 Tested
Activity against PROGEST/BO in the Eurofins Panlabs screen (BI) by Radioactive Assay
SummaryRelated BioAssays by Target
Activity against ESTROGEN/BO in the Eurofins Panlabs screen (BI) by Radioactive Assay
To determine the fetal calf serum protein binding, the plasma is diluted to 50 % with pH 7.4 phosphate buffer and warmed to 37 C before adding test compounds achieving 5 uM concentration. The dialysis buffer is added to one side of the chamber of the RED device, and the incubation is initiated by the addition of 300 uL of the test compound protein solution to the opposing chamber. The samples are incubated for 4 hours. Equal volumes from the buffer and the plasma chambers are transferred into separate wells. 50 uL of 50 % blank plasma are added to the buffer samples, and 50 uL of buffer are added to the 50 % plasma samples to ensure matrix matching of samples from both the free and bound fractions. Acetonitrile containing internal standard are added to precipitate the protein. The supernatants are analyzed by LC-MS/MS and the results are calculated. The assay has been performed by Concept Life Sciences Ltd.
Assay data:9 Tested
Summary
Inhibition of Bovine milk xanthine oxidase using xanthine as substrate assessed as decrease in uric acid level preincubated for 5 mins followed by substrate addition by spectrophotometric analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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